Radiomics for the prediction of EGFR mutation subtypes in non-small cell lung cancer

Medical Physics
Shu LiLei Wu

Abstract

This retrospective study was designed to investigate the ability of radiomics to predict the mutation status of epidermal growth factor receptor (EGFR) subtypes (19Del and L858R) in patients with non-small cell lung cancer (NSCLC). In total, 312 patients with NSCLC were included, and 580 radiomic features were extracted from the computed tomography images of each patient. In the training set, univariate analysis was performed on the clinical and radiomic features; logistic regression models were established using a 5-fold cross validation strategy for the prediction of EGFR subtypes 19Del and L858R. Subsequently, the predictive ability of the joint models was evaluated using the test set. The results revealed that the radiomic features specific for EGFR 19Del and L858R were Gabor's MTRVariance, Gabor's PTREntropy, and sphericity. Additionally, the respective areas under the receiver operating characteristic curves of the EGFR 19Del and L858R joint models were 0.7925 and 0.7750 for the test set. Our study demonstrated the potential for radiomics to predict EGFR 19Del and L858R. Epidermal growth factor receptor 19Del and L858R exhibited distinct imaging phenotypes, which may help to guide the selection of more accurate and person...Continue Reading

References

May 12, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pasi A JänneBruce E Johnson
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyVincent A Miller
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuankai ShiPan-Chyr Yang
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Feb 18, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Nesaretnam Barr KumarakulasingheRoss A Soo
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Mar 28, 2016·Clinical Lung Cancer·Ying LiuRobert J Gillies
Jul 17, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Samuel HawkinsRobert J Gillies
Oct 1, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stephen S F YipHugo J W L Aerts
Feb 1, 2017·Scientific Reports·Olivier GevaertAnn N Leung
Jun 2, 2017·Cancer Research·Emmanuel Rios VelazquezHugo J W L Aerts
Jan 2, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rajat ThawaniAnant Madabhushi
Jan 5, 2019·Medicine·Subba R DigumarthyMannudeep K Kalra

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Citations

May 6, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michele AvanzoGiovanna Sartor
Dec 29, 2020·Frontiers in Oncology·Diem VuongMarta Bogowicz
Jan 6, 2021·Journal of Clinical Medicine·Tania PereiraHélder P Oliveira
Aug 1, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Jaryd R ChristieSarah A Mattonen
Jun 21, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Isabella Fornacon-WoodGareth J Price
May 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Federico CucchiaraMarzia Del Re
Jul 3, 2021·Cancers·Agustina La Greca Saint-EstevenStephanie Tanadini-Lang

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