Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer

EBioMedicine
Yuming JiangGuoxin Li

Abstract

To develop and validate a radiomics signature for the prediction of gastric cancer (GC) survival and chemotherapeutic benefits. In this multicenter retrospective analysis, we analyzed the radiomics features of portal venous-phase computed tomography in 1591 consecutive patients. A radiomics signature was generated by using the Lasso-Cox regression model in 228 patients and validated in internal and external validation cohorts. Radiomics nomograms integrating the radiomics signature were constructed, demonstrating the incremental value of the radiomics signature to the traditional staging system for individualized survival estimation. The performance of the nomograms was assessed with respect to calibration, discrimination, and clinical usefulness. The radiomics signature consisted of 19 selected features and was significantly associated with DFS (disease-free survival) and OS (overall survival). Multivariate analysis demonstrated that the radiomics signature was an independent prognostic factor. Incorporating the radiomics signature into the radiomics-based nomograms resulted in better performance for the estimation of DFS and OS than the clinicopathological nomograms and TNM staging system, with improved accuracy of the classi...Continue Reading

Citations

Jul 28, 2019·Chinese Medical Journal·Yue Wang, Zheng-Yu Jin
Oct 31, 2019·Clinical and Translational Gastroenterology·Mingyu ChenUNKNOWN Written on behalf of the AME Gallbladder Cancer Collaborative Group
Oct 24, 2019·Journal of X-ray Science and Technology·Zong-Qiong SunJun Wang
Aug 7, 2020·Physics in Medicine and Biology·Hongzhen WuXinqing Jiang
Sep 26, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yanfen CuiXiaotang Yang
Jun 24, 2019·BJR Open·Michela GabelloniEmanuele Neri
Oct 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Hongmei WangKristen W Yeom
May 12, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Katja De Paepe, David Cunningham
Oct 28, 2020·Clinical and Translational Gastroenterology·Yuming JiangGuoxin Li
Jun 17, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Liwen ZhangJie Tian
Jul 27, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Yong ChenHuan Zhang
Sep 28, 2021·Frontiers in Oncology·Shixiong WuShuo Huang
Nov 27, 2021·Abdominal Radiology·Natally HorvatRichard K G Do

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Methods Mentioned

BETA
surgical resection
feature extraction
X-tile

Software Mentioned

SPSS
R
LASSO

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