Radionuclide angiographic determination of regional left ventricular systolic function during rest and exercise in patients with nonischemic cardiomyopathy treated with cardiac resynchronization therapy

The American Journal of Cardiology
Cinzia ValzaniaGiuseppe Boriani

Abstract

Cardiac resynchronization therapy (CRT) can improve global left ventricular (LV) function. However, limited data are available on regional LV contractility at rest and during exercise. The aim of the present study was to prospectively investigate the effects of CRT on regional LV ejection fraction (EF), global LVEF, and dyssynchrony, during rest and exercise, using radionuclide angiography. A total of 32 consecutive patients with heart failure and nonischemic cardiomyopathy underwent technetium-99m radionuclide angiography with bicycle exercise immediately after CRT implantation (during spontaneous rhythm and after CRT activation) and 3 months later. The regional EF was assessed in the interventricular septum and the lateral wall (LW). Intraventricular dyssynchrony was evaluated using Fourier phase analysis. During spontaneous rhythm, the EF was severely depressed in the septum compared to in the LW. CRT improved septal EF at rest and during exercise both at baseline (p <0.001) and after 3 months (p <0.05). The basal LW EF decreased during CRT (p <0.05, both at rest and during exercise). LV dyssynchrony decreased both at baseline and during follow-up, and the global LVEF showed improvement only at 3 months (p <0.001). In conclu...Continue Reading

References

Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Giuseppe BorianiAngelo Branzi
Feb 11, 2005·European Journal of Heart Failure·Oliver LindnerWolfgang Burchert
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
May 27, 2006·The American Journal of Cardiology·Pierre BordacharJacques Clementy
Feb 17, 2007·Pacing and Clinical Electrophysiology : PACE·Giuseppe BorianiAngelo Branzi
Mar 10, 2007·European Journal of Heart Failure·Cinzia ValzaniaFrieder Braunschweig
May 7, 2008·Circulation·Eugene S ChungJaime Murillo
Mar 25, 2009·Cardiology Clinics·Jeroen J BaxJoanne D Schuijf

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Citations

Jan 25, 2012·Revista Española De Cardiología·José F Forteza AlbertíRío Aguilar Torres
Jul 2, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Cinzia ValzaniaGiuseppe Boriani
Nov 27, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Cinzia ValzaniaNazzareno Galiè

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