Radionuclide Therapies in Prostate Cancer: Integrating Radium-223 in the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer

Current Oncology Reports
S Nilsson

Abstract

Metastatic castration-resistant prostate cancer (mCRPC) frequently metastasizes to the bone, often resulting in painful skeletal events, reduced quality of life, and reduced survival. The beta-emitting radiopharmaceuticals strontium-89 and samarium-153 alleviated pain in mCRPC patients with widespread skeletal metastases and have been associated with myelotoxicity. Radium-223, a first-in-class alpha-emitting radiopharmaceutical, prolonged overall survival, delayed symptomatic skeletal events, and improved quality of life, versus placebo, in patients with CRPC and symptomatic bone metastases and no visceral metastases. Radium-223 provided survival benefit to patients with CRPC and symptomatic bone metastases, regardless of prior docetaxel use. Importantly, prostate-specific antigen level and pain palliation were not a measure of radium-223 treatment response and should not alter the decision to administer all six radium-223 injections, the recommended regimen for survival benefit. Radium-223 was generally well tolerated, leading to ongoing clinical trials in combination with other therapeutics. Thus, radium-223 is a valuable addition to the mCRPC treatment armamentarium.

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Jun 21, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Yong DuVal Lewington
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Apr 2, 2021·ChemMedChem·Natalia Herrero ÁlvarezJason S Lewis

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Methods Mentioned

BETA
surgical castration

Clinical Trials Mentioned

NCT02278055
NCT02023697
NCT02346526
NCT02204943
NCT02141438
NCT02034552
NCT02463799
NCT02043678
NCT02398526
NCT01810770

Software Mentioned

REASSURE
TRAPEZE
ALSYMPCA

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