PMID: 11924759Apr 2, 2002Paper

Radioprotection by a herbal preparation of Hippophae rhamnoides, RH-3, against whole body lethal irradiation in mice

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
H C GoelA K Sinha

Abstract

Hippophae rhamnoides L. has been well documented to have anti-oxidative, immunostimulative and regenerative properties and therefore a herbal preparation of H. rhamnoides coded as RH-3 was investigated for its radioprotective action. RH-3 was administered intraperitonially (i.p.) to mice 30 minutes before whole body irradiation and whole body survival, spleen Colony forming units (CFU) and haematological parameters were studied. To investigate free radical scavenging and antioxidant potential, Fenton reaction, radiation mediated OH radical scavenging and chemically generated superoxide anions scavenging were studied in vitro while inhibition of lipid peroxidation was studied in liver homogenate of mice. A dose of 30 mg/kg body weight of RH-3 rendered 82% survival as compared to no survival in irradiated control. The endogenous CFU counts in mouse spleen on 10th post-irradiation day with and without RH-3 demonstrated radioprotective effect. Various hematological parameters also corroborated the radioprotective effect of RH-3. In a dose dependent manner, RH-3 inhibited Fenton reaction and radiation mediated generation of hydroxyl radicals in vitro, superoxide anion mediated Nitroblue tetrazolium (NBT) reduction and FeSO4 mediated...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 1, 1990·International Journal of Radiation Biology·E RiklisR Marko
Apr 1, 1990·International Journal of Radiation Biology·J F WeissE P Clark
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·M R LandauerJ F Weiss
Feb 19, 1996·Mutation Research·K ShimoiN Kinae
May 20, 1998·International Journal of Radiation Biology·J R Maisin

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Citations

Nov 8, 2003·The Journal of Pharmacy and Pharmacology·I Prem KumarH C Goel
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·Harish Chandra GoelMadhu Bala
Oct 1, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Madhu BalaJagdish Prasad
Jan 26, 2016·Medicinal Research Reviews·Mohammad Zahid KamranVibha Tandon
Mar 30, 2018·Frontiers in Pharmacology·Beata OlasKarolina Ulanowska
Jul 26, 2019·Expert Opinion on Therapeutic Patents·Inder Pal SinghGopabandhu Jena
Sep 24, 2005·Journal of Medicinal Food·Richa Gupta, S J S Flora
Jul 15, 2005·Molecular and Cellular Biochemistry·Rajesh AroraRakesh Kumar Sharma
Jun 18, 2010·Genome Génome / Conseil National De Recherches Canada·He LiBao-Quan Liu
Jul 31, 2010·International Journal of Radiation Biology·Lori RastogiKaushala Prasad Mishra
Mar 22, 2012·Journal of Dietary Supplements·Vanita GuptaManish Gupta
May 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wu ZhouYourui Suo
Aug 23, 2005·Phytotherapy Research : PTR·Said AmerYoshikazu Hirota
May 11, 2004·Journal of Radiation Research·Harish Chandra GoelRuchi Dogra
Jul 11, 2006·Journal of Medicinal Food·H C GoelR C Swahney
Apr 25, 2012·ISRN Pharmacology·Chirag A PatelJalaram H Thakkar
Jan 12, 2008·Journal of Clinical Biochemistry and Nutrition·Ganesh C Jagetia
Sep 2, 2006·Environmental and Molecular Mutagenesis·Sandeep Kumar ShuklaRakesh Kumar Sharma
Aug 21, 2013·Journal of Radiation Research·Hyang Ae ShinChul-Ho Kim
Mar 31, 2005·Phytotherapy Research : PTR·Rajesh AroraRakesh Kumar Sharma
Oct 6, 2020·Journal of Ethnopharmacology·Swati PundirPoonam Negi
Oct 4, 2011·Journal of Ethnopharmacology·Geetha Suryakumar, Asheesh Gupta

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