Radioprotective Agents and Enhancers Factors. Preventive and Therapeutic Strategies for Oxidative Induced Radiotherapy Damages in Hematological Malignancies

Antioxidants
Andrea Gaetano AllegraAlessandro Allegra

Abstract

Radiation therapy plays a critical role in the management of a wide range of hematologic malignancies. It is well known that the post-irradiation damages both in the bone marrow and in other organs are the main causes of post-irradiation morbidity and mortality. Tumor control without producing extensive damage to the surrounding normal cells, through the use of radioprotectors, is of special clinical relevance in radiotherapy. An increasing amount of data is helping to clarify the role of oxidative stress in toxicity and therapy response. Radioprotective agents are substances that moderate the oxidative effects of radiation on healthy normal tissues while preserving the sensitivity to radiation damage in tumor cells. As well as the substances capable of carrying out a protective action against the oxidative damage caused by radiotherapy, other substances have been identified as possible enhancers of the radiotherapy and cytotoxic activity via an oxidative effect. The purpose of this review was to examine the data in the literature on the possible use of old and new substances to increase the efficacy of radiation treatment in hematological diseases and to reduce the harmful effects of the treatment.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J E BiaglowK Held
Dec 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V MengeaudP Rampal
Dec 11, 1990·Nucleic Acids Research·G A Cortopassi, N Arnheim
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·A Bosch, Z Frias
May 1, 1989·Immunology Letters·A KharazmiK Bendtzen
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J E BiaglowK D Held
Jun 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E E VokesR R Weichselbaum
Oct 1, 1988·International Journal of Radiation Biology·G C GobéD J Allan
Jan 1, 1986·Biochemical Pharmacology·J E BiaglowE J Hall
Jun 1, 1986·The British Journal of Radiology·H R WithersH D Thames
Apr 1, 1980·The British Journal of Radiology·P Ash
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Aug 15, 1998·Biochemical and Biophysical Research Communications·Z MaoS C Lu
Apr 27, 2000·American Journal of Respiratory Cell and Molecular Biology·N S WardJ A Elias
Feb 22, 2001·Radiation Research·M E RobbinsS M Bonsib
Mar 21, 2001·Apoptosis : an International Journal on Programmed Cell Death·H U SimonF Levi-Schaffer
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·D MagdaR A Miller
Nov 24, 2001·Mechanisms of Ageing and Development·Glenn S GerhardChristopher D Gocke
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter M AndersonOyvind S Bruland
Feb 12, 2002·Radiation Research·John E MoulderThomas J Raife
Jun 19, 2002·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Gernot WeibrichWalter E Hitzler
Aug 9, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Mustafa SarsilmazOmer Akyol
Aug 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·C LinardD Mathe
Sep 19, 2003·Seminars in Nephrology·Eric P Cohen, Mike E C Robbins
Aug 20, 1963·Biochemical and Biophysical Research Communications·G E ADAMS, D L DEWEY
Feb 13, 2004·International Journal of Cancer. Journal International Du Cancer·Séverine ColasPhilippe Bougnoux
May 27, 2004·Cytogenetic and Genome Research·G IliakisG Pantelias
Sep 24, 2004·Cell Biochemistry and Function·Irfan KukuM Ali Erkurt
Dec 17, 2004·The New England Journal of Medicine·Ricardo SpielbergerChristos Emmanouilides
May 10, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robert M HermannHeinz Schmidberger
May 18, 2005·Biochemical and Biophysical Research Communications·Béatrice ChabiGeorges Stepien
Jul 1, 2005·Journal of Radiation Research·Ira SkvortsovaPeter Lukas
Jul 30, 2005·Mitochondrion·Nicolai Balle LarsenLene Juel Rasmussen
Oct 12, 2005·Archives of Neurology·Antonio M P OmuroLauren E Abrey

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
X-ray
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.