PMID: 20112872Feb 2, 2010Paper

Radioprotective effect of lycopene on chromosomal aberrations (CAs) induced by gamma radiation in human lymphocytes

Journal of Environmental Biology
Kültiğin Cavuşoğlu, Emine Yalçin

Abstract

The present study was carried out to evaluate the radioprotective role of lycopene on chromosomal aberrations (CAs) induced by gamma (gamma) radiation in human lymphocytes. For this purpose, we used in vitro dose-effect relationship, and correlate these data with statistical parameters. CAs were evaluated in terms of chromosome break, dicentric, tricentric, acentric, fragment and ring. Mitotic index (MI) and aberrant metaphase number (AMN) were also calculated. Nine groups of lymphocyte culture were prepared: (I) Control group did not received radiation or lycopene, (II) positive control; lymphocytes were treated only with 0.020 microM lycopene, (III) radiation group; lymphocytes were treated with only 10 Gy gamma-radiation, (IV) lymphocytes were treated with 0.001 microM lycopene before irradiation, (V) lymphocytes were treated with 0.005 microM lycopene before irradiation, (VI) lymphocytes were treated with 0.010 microM lycopene before irradiation, (VII) lymphocytes were treated with 0.015 microM lycopene before irradiation, (VIII) lymphocytes were treated with 0.018 microM lycopene before irradiation, (IX) lymphocytes were treated with treated with 0.020 microM lycopene before irradiation. The results indicated that all lyco...Continue Reading

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