PMID: 8599994Jan 1, 1996Paper

Radioprotective effects of combination broncho-vaxom, a macrophage activator, and indomethacin, an inhibitor of prostaglandin production: relationship to myelopoiesis

European Journal of Haematology
P Fedorocko, O Macková

Abstract

The effects of the bacterial extract broncho-vaxom (BV; radioprotective immunomodulator; 500 micrograms/mouse i.p., -24 h) and indomethacin (INDO; inhibitor of prostaglandin production; 2 x 40 micrograms/mouse i.m., -24 h and -3 h) on the post-irradiation recovery of hemopoietic functions in mice were investigated. Both agents were administered either alone or in combination. Endogenous spleen colony formation was increased in all treatment groups, with combination-treated mice exhibiting the greatest effects. Similarly, 24 h after combined administration of BV and INDO (i.e. at the time of presumed irradiation) to the non-irradiated mice granulocyte-macrophage colony-forming cell (GM-CFC) numbers were greater in the bone marrow and spleen. Also, as determined by hydroxyurea injection, there was an increase in the number of GM-CFC in the S-phase of the cell cycle in the bone marrow. However, GM-CFC in the spleen of combination pretreated mice was not stimulated to significant proliferation as compared to GM-CFC in the spleen of mice injected with BV alone. Combined modality treatment was also more effective than single agent treatments in accelerating bone marrow cellularity and GM-CFC regeneration, but not in accelerating GM-C...Continue Reading

References

Apr 1, 1992·International Journal of Radiation Biology·P FedorockoN O Macková
Jan 1, 1988·Pharmacology & Therapeutics·M A Chirigos, M L Patchen
Jan 1, 1987·Immunopharmacology and Immunotoxicology·G N SchwartzR Neta
Jan 1, 1984·International Journal of Immunopharmacology·G J Maestroni, G A Losa
Jan 1, 1980·Respiration; International Review of Thoracic Diseases·J M PuigdollersJ J Torroella

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Citations

Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Tat Khuen Lee, Ieva Stupans
Jun 8, 2001·Journal of Radiation Research·C K NairT Nomura
Nov 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferMartin Falk
May 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferDenisa Komůrková

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