Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells

The British Journal of Radiology
Seyed Jalal Hosseinimehr, A Nemati

Abstract

The radioprotective effects of hesperidin (HES), a flavonone glucoside, were investigated by using the micronucleus test for anticlastogenic and cell proliferation activity. A single intraperitoneal (ip) administration of hesperidin at doses of 10 mg kg(-1), 20 mg kg(-1), 40 mg kg(-1), 80 mg kg(-1) and 160 mg kg(-1) 45 min prior to gamma irradiation (2 Gy) reduced the frequencies of micronuleated polychromatic erythrocytes (MnPCEs). All five doses of HES significantly reduced the frequencies of MnPCEs and increased PCE/PCE+NCE ratio in mice bone marrow compared with non-drug-treated irradiated control (p<0.0001). There was a drug dose-response effect of HES in reducing MnPCE and increasing the PCE/PCE+NCE ratio in bone marrow cells. The maximum reduction in MnPCE was observed in mice treated with HES at a dose of 80 mg kg(-1). The total MnPCE values were 2.85 fold less in the 80 mg kg(-1) HES group after being exposed to 2 Gy of gamma-rays than those in the respective irradiated control. Our study demonstrates that hesperidin has powerful protective effects on the radiation-induced DNA damage and on the decline in cell proliferation in mouse bone marrow.

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Apr 16, 2005·The Journal of Pharmacy and Pharmacology·Seyed Jalal Hosseinimehr, Mohmmad Karami

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Citations

May 10, 2013·Journal of Helminthology·G Allam, A S A Abuelsaad
Sep 5, 2008·Radiation and Environmental Biophysics·Seyed Jalal HosseinimehrShahram Akhlaghpoor
Jun 20, 2008·Archives of Pharmacal Research·Amirhosein AhmadiMehran Ghahremani
Sep 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SugiuraM Yano
May 19, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SugiuraM Yano
Dec 23, 2009·Cancer Biotherapy & Radiopharmaceuticals·Seyed Jalal Hosseinimehr
Jan 26, 2016·Medicinal Research Reviews·Mohammad Zahid KamranVibha Tandon
Apr 8, 2015·Natural Product Research·Roumiana Todorova, Atanas T Atanasov
Mar 5, 2011·European Journal of Pharmacology·Kalyanasundaram Banumathy KalpanaVenugopal Padmanaban Menon
Feb 4, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·P A OmololuI J Kade
Sep 2, 2009·Nuclear Medicine and Biology·Seyed Jalal HosseinimehrAziz Mahmoudzadeh
May 19, 2009·European Journal of Pharmacology·Xiaoling LuZesheng Zhang
Oct 16, 2007·Drug Discovery Today·Seyed Jalal Hosseinimehr
May 28, 2009·Environmental and Molecular Mutagenesis·Seyed Jalal HosseinimehrSoheila Mohamadifar
Sep 22, 2011·Mutation Research·Archana P RB S Satish Rao
Oct 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tandeka MagcwebebaWentzel Gelderblom
Oct 17, 2013·Chemistry & Biodiversity·Vesna S KuntićSnežana M Uskoković-Marković
Sep 8, 2018·Journal of Periodontology·Po-Jan KuoHsien-Chung Chiu
Mar 8, 2017·Journal of Biological Research·Nadia Z ShabanAhmad S Abdo Kodous
Jun 29, 2012·Integrative Cancer Therapies·Seyed Jalal HosseinimehrAziz Mahmoudzadeh
Jul 25, 2019·Medicina·Ahmed Eleojo MusaDheyauldeen Shabeeb
Dec 23, 2006·Journal of Radiation Research·Seyed Jalal HosseinimehrShahram Akhlaghpoor
Feb 6, 2016·International Journal of Biological Macromolecules·Halina Malgorzata ZbikowskaAlicja Klaudia Olejnik

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