PMID: 6972364May 1, 1981Paper

Radiosensitivity and postirradiation changes of bone marrow clonogenic stromal mechanocytes

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
A J FriedensteinS Y Sidorovich

Abstract

The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). D0 of the CFU-F survival curve proved to be about 200 rad, while n is 1.4. Immediately after total-body exposure to 400 rad and to local exposure of tibias to 400 rad, the number of CFU-F diminishes in accordance with D0; it sharply increases after 6 hours and then decreases again. In the period between the eighth and twelfth day following local irradiation, the number of CFU-F doubled in the course of 30-35 hours but later the rate of recovery slowed down. Practically no CFU-F were traced during 3 months after local exposure to 2 krad.

References

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Aug 1, 1971·Transplantation·A Friedenstein, A I Kuralesova
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Citations

Oct 7, 2006·Biochemical and Biophysical Research Communications·C ColnotJ Helms
Jul 24, 2014·BioMed Research International·Daniela GalliMauro Vaccarezza
Jun 6, 2012·Stem Cells International·Sally A Boxall, Elena Jones
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Jul 1, 1988·The Annals of Otology, Rhinology, and Laryngology·M JacobssonI Turesson

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