PMID: 3759577Aug 1, 1986Paper

Radiosensitization by diamide analogs and arsenicals

International Journal of Radiation Oncology, Biology, Physics
E A BumpJ M Brown

Abstract

Several analogs of the glutathione (GSH) oxidizing reagent diamide [diazenedicarboxylic acid bis(N,N'-diethylamide)] were tested as radiosensitizers of aerobic cells. In general, radiosensitization correlates with the rate of reaction with cellular reducing agents and occurs only when the reductive capacity of the cell is exceeded. SR-4077, [diazenedicarboxylic acid bis(N,N-piperidide)], is particularly suitable for mechanistic studies, because it is less cytotoxic than diamide, but is equally reactive toward cellular GSH. SR-4077 sensitizes CHO cells to X rays under aerobic conditions, even when the drug is added after irradiation. Radiosensitization is expressed both as a change in the exponential slope of the radiation cell survival curve and as a decrease in the shoulder of the survival curve. Phenylarsine oxide, a dithiol-binding reagent, sensitizes aerobic CHO cells to X rays by modification of the shoulder of the survival curve. The results are consistent with the hypothesis that the shoulder-modifying effect of GSH oxidants is caused by the loss of protein thiols, which might be involved in the repair of X ray-induced DNA damage.

References

Jan 1, 1979·Pharmacology & Therapeutics·J W Harris
Mar 10, 1972·Biochemical and Biophysical Research Communications·J W Harris, J E Biaglow
Sep 1, 1972·The Journal of Pathology·C L Berry, J Germain
Nov 6, 1969·Biochemical and Biophysical Research Communications·N S KosowerW S Correa
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·E A BumpJ M Brown

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·E A Bump, J M Brown
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Mark de RidderGuy A Storme
Jul 1, 1990·Environmental Health Perspectives·R G Stevens, D R Kalkwarf
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·E M Zeman, J M Brown
May 15, 1994·International Journal of Radiation Oncology, Biology, Physics·E A BumpC N Coleman
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G Iliakis, S Kurtzman
Jan 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E A BumpC N Coleman
Jan 1, 1990·Critical Reviews in Oncology/hematology·C N Coleman, A T Turrisi
Jul 2, 2003·Leukemia·Y-K KeungB L Powell
Feb 24, 2006·Radiation Research·John E BiaglowJohn J Mieyal

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