PMID: 6974144Aug 1, 1981Paper

Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
G E AdamsC Williamson

Abstract

The efficiencies of various 5-substituted-4-nitroimidazoles as radiation sensitizers have been determined in hypoxic Chinese hamster cells irradiated in vitro. Compared with published data on the sensitizing properties of substituted 2-nitro- and 5-nitroimidazoles, some of the 4-nitro derivatives show unusually high sensitizing efficiencies defined as the concentrations required to give an enhancement ratio of 1.6. The equilibrium one-electron reduction potentials of the compounds (E17) were measured by a pulse radiolysis technique and the results show that although sensitizing efficiencies are unexpectedly high, based on considerations of electron affinity, they still increase with increasing values of E17. Enhancement ratios were determined in two V79 cell lines for combinations of one of these compounds (a 4-nitroimidazole containing the group SO2.O.phenyl in the 5-position, NSC 38087) with various concentrations of misonidazole. The sensitization observed suggests that the two compounds may be operating by different mechanisms.

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Citations

May 1, 1995·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M UranoJ Begley
Jan 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C Z Chen, D E Watt
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G E AdamsI J Stratford
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J M Brown
Nov 22, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Francesca MalentacchiClaudio Orlando

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