Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione

Science
E A BumpJ M Brown

Abstract

Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.

Citations

Mar 4, 2000·Journal of Cellular Physiology·S H BaekY M Park
Jan 15, 1989·Experientia·A Rojas, J Denekamp
Jan 1, 1986·Biochemical Pharmacology·J E BiaglowE J Hall
Jan 1, 1990·Pharmacology & Therapeutics·X Q ShanD P Jones
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Erden
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G StevensJ Denekamp
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·A MoralesJ C Fernández-Checa
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H PoppenborgH J Galla
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G L Jensen, A Meister
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C Borek, W Troll
Apr 1, 1990·Journal of Neurosurgery·H KudoS Matsumoto
Apr 1, 1985·The British Journal of Radiology·D C Shrieve, J Denekamp
Jan 1, 1984·Radiation and Environmental Biophysics·A W KoningsM B Yatvin
Nov 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J E BiaglowJ B Mitchell
Apr 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A S BellamyB T Hill
Sep 1, 1986·International Journal of Radiation Oncology, Biology, Physics·T L PhillipsE Glatstein
Sep 1, 1986·International Journal of Radiation Oncology, Biology, Physics·K OnoM Abe
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·T L PhillipsR K Rajpal
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·W G DeGraffJ B Mitchell
Mar 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J M Brown
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·C C LingR A Basas
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·E P Clark
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J B MitchellA Russo
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C M ArundelA S Glicksman
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A Russo, J B Mitchell
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·O VosW S Roos-Verhey
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·N Y Yu, J M Brown
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·I J SpiroC C Ling
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·B R Smith, J L Born
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·T H Wasserman
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J M Brown
May 15, 1994·International Journal of Radiation Oncology, Biology, Physics·C J Koch, K A Skov
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·T T Kwok, R M Sutherland
Jun 11, 1992·Toxicology and Applied Pharmacology·J W BaumanC D Klaassen
Jan 1, 1990·Critical Reviews in Oncology/hematology·C N Coleman, A T Turrisi
Jun 1, 1990·Biochemical Medicine and Metabolic Biology·M P CornagoM C Izquierdo
Aug 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R A BrittenJ A Green
Jul 29, 1998·Chemico-biological Interactions·P CalvertP J O'Dwyer
Jul 31, 1984·Biochemical and Biophysical Research Communications·R F Cordeiro, T M Savarese
Mar 4, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·Y Zhang, S G Martin
May 1, 1985·Cancer·J M Brown
Jan 24, 2019·Cancers·Hui WangMark De Ridder
Aug 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D FrankenbergF Eckardt-Schupp
Sep 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M E WattsM R Stratford
Oct 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P J DeschavanneE P Malaise
Nov 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R J HodgkissM Woodcock
Dec 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P ToddM Edgren
Jun 1, 1991·International Journal of Radiation Biology·A I Minchinton, D J Chaplin
Jun 8, 2001·Journal of Radiation Research·C K NairT Nomura
Jul 1, 2020·Experimental Biology and Medicine·Sukanya RoySanjukta Chakraborty
May 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·B C Millar, S Jinks
Jul 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·O VosW S Roos-Verheij
Feb 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·O Vos, W S Roos-Verhey
Oct 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D DebieuE P Malaise
Sep 8, 2018·Oncotarget·Lara CoblerLuika A Timmerman
Oct 1, 1988·International Journal of Radiation Biology·R J Hodgkiss, M R Stratford
Mar 1, 1986·The British Journal of Radiology·O C Scott
Jan 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P J DeschavanneL Revesz
Aug 1, 1990·International Journal of Radiation Biology·M Rybczynska
Sep 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G P van der SchansP H Lohman
Mar 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J MidanderL Revesz

Related Concepts

Diethyl maleate
Metazoa
Anoxemia
Cell Survival
Cricetulus
Drug Augmentation
Reduced Glutathione
Cricetus
Maleates
Mice, Inbred BALB C

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
T L PhillipsE Glatstein
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
A RojasJ Denekamp
International Journal of Radiation Oncology, Biology, Physics
J E BiaglowL A Dethlefsen
© 2021 Meta ULC. All rights reserved