PMID: 5910191Apr 22, 1966

Radiosensitization of X chromosome of Chinese hamster cells related to incorporation of 5-bromodeoxyuridine

Science
W C DeweyR M Humphrey

Abstract

Selective incorporation of 5-bromodeoxyuridine into the late replicating arm of the X chromosome of Chinese hamister cells cultured in vitro caused a selective radiosensization of the arm to ionizing radiation. Radiation damage was observed as chromosomal aberrations, and incorporation was studied by using tritiated 5-bromodeoxyuridine.

Citations

Mar 1, 1979·Mutation Research·W F Benedict, P A Jones
Oct 5, 2010·Journal of the American Chemical Society·Chun-Rong Wang, Qing-Bin Lu
Jun 26, 2012·The Journal of Physical Chemistry. a·Jing ChenJ V Ortiz
Feb 24, 2011·The Journal of Chemical Physics·Xiang LiKit H Bowen
Jan 12, 2011·The Journal of Chemical Physics·Dunja RadisicKit H Bowen
Aug 16, 2011·Journal of Pharmaceutical and Biomedical Analysis·Barbara MichalskaJanusz Rak
Jan 22, 2011·Bioorganic & Medicinal Chemistry Letters·Ambadas B RodeSung Hee Hong
Nov 19, 2004·Radiation Research·Sylvain CecchiniDarel J Hunting
Apr 28, 2009·European Journal of Cell Biology·Phillip KarpowiczDerek van der Kooy
Mar 30, 2011·The Journal of Physical Chemistry. B·Piotr StoroniakLluís Blancafort
Jan 1, 1967·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M Fox, L G Lajtha
Jan 16, 2017·The Journal of Chemical Physics·Xiaojuan DaiHongmei Su

Related Concepts

NSC-38297
Autosome Abnormalities
Chromosomes
Cricetus
Radiation Genetics
Nuclear Track Detection
Thymidine
Tritium
Autosomal Chromosome Disorders
Culture Techniques

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