Radiosensitizing effect of curcumin-loaded lipid nanoparticles in breast cancer cells

Scientific Reports
Luigi MinafraGiusi Irma Forte

Abstract

In breast cancer (BC) care, radiotherapy is considered an efficient treatment, prescribed both for controlling localized tumors or as a therapeutic option in case of inoperable, incompletely resected or recurrent tumors. However, approximately 90% of BC-related deaths are due to the metastatic tumor progression. Then, it is strongly desirable to improve tumor radiosensitivity using molecules with synergistic action. The main aim of this study is to develop curcumin-loaded solid nanoparticles (Cur-SLN) in order to increase curcumin bioavailability and to evaluate their radiosensitizing ability in comparison to free curcumin (free-Cur), by using an in vitro approach on BC cell lines. In addition, transcriptomic and metabolomic profiles, induced by Cur-SLN treatments, highlighted networks involved in this radiosensitization ability. The non tumorigenic MCF10A and the tumorigenic MCF7 and MDA-MB-231 BC cell lines were used. Curcumin-loaded solid nanoparticles were prepared using ethanolic precipitation and the loading capacity was evaluated by UV spectrophotometer analysis. Cell survival after treatments was evaluated by clonogenic assay. Dose-response curves were generated testing three concentrations of free-Cur and Cur-SLN in co...Continue Reading

References

Feb 27, 2004·Oncogene·Damodaran ChendilMansoor M Ahmed
Feb 25, 2005·Investigative Ophthalmology & Visual Science·Hyun-Seung KimDe-Quan Li
Dec 8, 2006·Carcinogenesis·Naghma KhanHasan Mukhtar
Jun 16, 2007·Advances in Experimental Medicine and Biology·Ganesh C Jagetia
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry BartelinkLaurence Collette
Jun 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Philip WongCarolyn R Freeman
Jul 19, 2011·European Journal of Pharmacology·Abdelazim IbrahimRola Barhoumi
Aug 13, 2011·Cancer Prevention Research·Sharanjot SainiRajvir Dahiya
Aug 19, 2011·Molecular Systems Biology·Daniela GaglioFerdinando Chiaradonna
Aug 25, 2011·Genome Medicine·Catharine M West, Gillian C Barnett
Mar 16, 2012·International Journal of Radiation Oncology, Biology, Physics·Takahiro OikeTakashi Kohno
Jul 31, 2012·Journal of Radiation Research·Meetha MedhoraAniko Szabo
Nov 30, 2012·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Feb 21, 2013·Omics : a Journal of Integrative Biology·Valentina BravatàLuigi Minafra
Mar 26, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I MeattiniG Biti
Jul 13, 2013·Molecular and Cellular Biochemistry·Sojung ParkInki Kim
Jan 1, 2014·Frontiers in Molecular Biosciences·Rajamanickam BaskarKheng-Wei Yeoh
Nov 18, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Lixing GanXuejun Guo
Nov 23, 2016·Critical Reviews in Food Science and Nutrition·Muhammad ImranHafiz Ansar Rasul Suleria
Dec 19, 2016·Molecular Nutrition & Food Research·Masaki KatoTakanori Tsuda
Jan 24, 2017·Journal of Agricultural and Food Chemistry·Maria Luisa BondìMelchiorre Cervello
Sep 16, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sujuan WangXinwu Ba
Jul 20, 2018·European Journal of Medicinal Chemistry·Jie Quan WangXin Hua Liu

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Citations

Sep 27, 2019·International Journal of Molecular Sciences·Francesco P CammarataGiorgio Russo
Oct 28, 2019·Nutrition and Cancer·Katrin Sak
Oct 28, 2019·International Journal of Molecular Sciences·Marco CalvarusoLuigi Minafra
Mar 4, 2020·Scientific Reports·Katharina SchwarzStephanie E Combs
Sep 5, 2020·International Journal of Molecular Sciences·Francesco P CammarataGiorgio Russo
Jun 25, 2020·International Journal of Molecular Sciences·Wei-Hsun WangJeng-Jong Hwang
Jul 8, 2020·International Journal of Radiation Oncology, Biology, Physics·Alexandre DetappePeter P Ghoroghchian
Jan 19, 2021·BioMed Research International·Ke YangChenxia Hu
Feb 4, 2021·Scientific Reports·Giuseppe SergioliRoberto Giuntini
Mar 27, 2021·Investigational New Drugs·Nurul A AbdullahStewart G Martin
Sep 21, 2021·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mostafa A AskarAmal M Hanafy

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Datasets Mentioned

BETA
GSE118061
MDA-MB-231

Methods Mentioned

BETA
metabolomic profiling
nuclear translocation
acetylation

Software Mentioned

DAVID
Mass Profile Professional ( MPP )
Agilent Muss Hunter
SLN
GeneSpring GX
Cur
Database for Annotation , Visualization and Integrated Discove...

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