PMID: 3759592Sep 1, 1986Paper

Radiosensitizing effect of misonidazole in combination with an inhibitor of glutathione synthesis in murine tumors

International Journal of Radiation Oncology, Biology, Physics
K OnoM Abe

Abstract

The radiosensitizing effects of misonidazole (MISO) in combination with D,L-buthionine-S, R-sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, were studied in NFSa tumors of C3H/He mice. The radiation response of tumors was assayed by the tumor growth delay time. The GSH contents in tissues were assayed by high performance liquid chromatography (HPLC). GSH content in the tumors decreased to the minimum level (45% of the control), and then gradually recovered to 75% of the control, respectively, 12 and 24 hr after the intraperitoneal injection of 5 mmole/kg BSO. On the other hand, the maximum non-protein sulfhydryl (NPSH) depletion (29% of the control) in the liver of tumor bearing mice was achieved 6 hr after the administration of the same dose of BSO, but fully recovered 24 hr later. When 5 mmole/kg BSO was injected repeatedly 4 times at an interval of 6 hr, GSH content in the tumors decreased to 19% of the control 24 hr after the first injection of BSO. The radiosensitizing effect of 0.5 mmole/kg MISO was markedly increased by this BSO treatment. The enhancement ratio (ER) of this combined treatment was 1.93. On the other hand, ERs of 1.44 and 1.16 were obtained for MISO (0.5 mmole/kg) and for 4 injections of ...Continue Reading

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·E A Bump, J M Brown
Jan 1, 1990·Pharmacology & Therapeutics·G S AhluwaliaD A Cooney
Nov 16, 2002·Archives of Pharmacal Research·Nguyen-Hai NamByung-Zun Ahn
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May 12, 2021·ACS Nano·Xiaotong ChengFu-Gen Wu
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·N J McNally, J A Soranson

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