PMID: 9164686May 1, 1997Paper

Radiosurgery and accelerated radiotherapy for patients with glioblastoma

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
G ShenoudaG Mohr

Abstract

To assess the feasibility, toxicity, and local control of stereotactic radiosurgery followed by accelerated external beam radiotherapy (AEBR) for patients with glioblastoma multiforme. Six males and eight females, with a median age of 67.5 years (range 45-78 years), entered the study. Karnofsky performance status was 90 for five, 80 for six, and 60 for three patients. Following surgery, the patients were left with a residual mass 4 cm. Radiosurgery was delivered with a single dose of 20 Gy to the 90% isodose surface corresponding to the contrast-enhancing edge of the tumour. A total AEBR dose of 60 Gy in 30 fractions was delivered using a concomitant boost technique over four weeks. Median survival time was 40 weeks (range 17-80 weeks). Actuarial survivals at 12 and 18 months were 43% and 14%, respectively. The median time to progression was 25 weeks (range 2-77 weeks). One patient developed a seizure on the day of stereotactic radiosurgery. Two patients experienced somnolence at 47 and 67 days post-radiotherapy. Eight patients remained steroid-dependent. Radiological evidence of leukoencephalopathy was observed in one patient, and brain necrosis in two additional patients at 30 and 63 weeks. One of these two patients with brai...Continue Reading

References

Sep 1, 1979·Cancer·T Hoshino, C B Wilson
Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M D WalkerG E Sheline
Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·O M SalazarR Pizzutiello
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C O ScharfenK R Lamborn
Feb 1, 1992·Journal of Neurosurgery·R C FlorellJ G Cairncross
Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·L SouhamiG B Pike
Apr 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J S LoefflerE Alexander
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J F Fowler
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·K E WallnerM G Malkin
Nov 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C M LudgateG B Goodman
May 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H KeimK R Trott
Jan 1, 1986·International Journal of Radiation Oncology, Biology, Physics·A J Gray
Sep 1, 1987·Medical Physics·B PikeC Pla
Jan 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E B PodgorsakJ Hazel
May 1, 1985·Cancer·H R Withers
Jan 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C C WangP H Blitzer
Jul 1, 1972·Journal of Neurosurgery·T HoshinoD Fewer
Sep 1, 1980·Neurology·F H Hochberg, A Pruitt
Oct 1, 1982·International Journal of Radiation Oncology, Biology, Physics·R E Peschel, J J Fischer
Feb 1, 1983·International Journal of Radiation Oncology, Biology, Physics·H D ThamesG H Fletcher
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D GannettA Hamilton

❮ Previous
Next ❯

Citations

Nov 30, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T MuanzaA Langleben
Apr 13, 2010·Journal of Neuro-oncology·Christopher J AnkerDennis C Shrieve
Aug 23, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Q Al HinaiR Leblanc
Jun 10, 2020·Radiation Oncology·Jane-Chloe TroneEdouard Ollier
Apr 12, 2003·Technology in Cancer Research & Treatment·David Roberge, Luis Souhami
Jan 10, 2008·Expert Review of Anticancer Therapy·Catherine S HwangKenji Muro
Sep 16, 2016·Journal of Neuro-oncology·Ted K YanagiharaTony J C Wang
May 1, 1997·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·N J Laperriere, M Bernstein
Dec 15, 2004·American Journal of Clinical Oncology·Robert A LustigWalter J Curran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Surgery
M BockhornJ R Izbicki
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
I S Kay, W E Davies
© 2021 Meta ULC. All rights reserved