PMID: 11334268May 4, 2001Paper

Radiosurgical management of benign cavernous sinus tumors: dose profiles and acute complications

Neurosurgery
J C ChenMichael L J Apuzzo

Abstract

Radiosurgery has emerged as an alternative treatment modality for cranial base tumors in patients deemed not suited for primary surgical extirpation, patients with recurrent or residual tumor after open surgery, or patients who refuse surgical treatment. We review our short-term experience with radiosurgical management of cavernous sinus region tumors with the Leksell gamma knife. From August 1994 to February 1999, 69 patients with cavernous sinus lesions were treated in 72 separate treatment sessions. The tumor type distribution was 29 pituitary adenomas, 35 meningiomas, 4 schwannomas, and 1 paraganglioma. The median follow-up was 122 weeks. Lesions were stratified according to a five-level surgical grade. The grade distribution of the tumors was as follows: Grade I, 13; Grade II, 21; Grade III, 19; Grade IV, 12; Grade V, 4. Median tumor volume was 4.7 cm3. The median radiation dose was 15 Gy to the 50% isodose line. Median maximal radiation dose was 30 Gy. Analysis of tumor characteristics and radiation dose to optic nerve and pontine structures revealed a significant correlation between distance and dose. Much lower correlation coefficients were found between tumor volume and dose. One lesion in this series had evidence of t...Continue Reading

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Citations

Jul 25, 2006·Neurosurgical Focus·L Fernando GonzalezRobert F Spetzler
Oct 17, 2007·Journal of Neurosurgery·Toshinori HasegawaDai Ishii
Sep 24, 2016·Japanese Journal of Radiology·Selcuk DemiralMurat Beyzadeoglu
Jan 27, 2005·Neurosurgical Focus·Rodrigo Couto TorresMichael Selch
May 2, 2008·Neurosurgical Focus·Samer GhostineWalter D Johnson
Jun 15, 2007·Journal of Neurosurgery·Jay JagannathanMary Lee Vance
Mar 17, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yang LiuRenzhi Wang
Jan 27, 2005·Neurosurgical Focus·Thomas C Witt
Apr 30, 2005·Stereotactic and Functional Neurosurgery·A-Li LiuPeng Liu
Aug 11, 2017·Stereotactic and Functional Neurosurgery·Maziar AzarMohammad Farhadi

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