Abstract
Multivariate analysis of prognostic factors influencing survival and bladder preservation after radiochemotherapy for bladder cancer following transurethral resection of the bladder (TURB). At the University Hospital of Erlangen 333 patients with bladder cancer were treated with either radiotherapy alone (RT, n = 128) or platin based radiochemotherapy (RCT, n = 205) after TURB between 5/1982 and 5/1996. Two-hundred and eighty-two curative patients, with either muscle invasive or T1-high risk cancer, were analyzed. Median age was 66 years, median follow-up is 7.5 years. Uni- and multivariate analysis was performed for age, grade, R-status after initial TURB, T-category and treatment modality relevant to the endpoints initial response, survival and bladder preservation. Treatment related mortality was below 1%. Complete remissions were achieved at 57%, 70%, and 85% after RT or RCT with carboplatin or cisplatin. This difference was multivariately significant. Further significant prognostic factors were pT-category and R-status. For all patients survival was 59% and 43% after 5 and 10 years. 79% of survivors could keep their own bladder. Five-year survival rates after RT alone, RCT with carboplatin or cisplatin were 47%, 57%, and 6...Continue Reading
References
Feb 1, 1977·The Journal of Urology·D E Johnson, S M Lamy
Jan 1, 1992·Urology·K I WishnowR J Babaian
Jan 1, 1991·The Journal of Urology·F PaganoA Garbeglio
Jul 1, 1987·The Journal of Urology·D P WoodG J Beck
Aug 21, 1987·JAMA : the Journal of the American Medical Association·W U ShipleyM D Hafermann
Feb 1, 1981·Urology·R B BrackenD E Johnson
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·J DunstA Altendorf-Hofmann
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·A L Zietman, W U Shipley
Apr 1, 1994·Cancer·M S SolowayY Lu
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M HoussetF Baillet
Sep 1, 1993·International Journal of Radiation Oncology, Biology, Physics·A L ZietmanD S Kaufman
Nov 4, 1993·The New England Journal of Medicine·D S KaufmanJ T Efird
Jun 15, 1993·Cancer·H A FrazierD F Paulson
Feb 17, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P MartusR Sauer
Citations
Nov 11, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J DunstA Becker
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C N Sternberg
Mar 27, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S BirkenhakeR Sauer
Aug 27, 2002·Current Treatment Options in Oncology·Fabio Calabrò, Cora N Sternberg
Apr 6, 2001·Seminars in Surgical Oncology·J DunstW U Shipley
Jun 19, 2008·Nature Clinical Practice. Urology·Vito Pansadoro, Paolo Emiliozzi
Apr 4, 2003·Cancer·Sana Al-Sukhun, Maha Hussain
Jul 3, 2013·Cancer Control : Journal of the Moffitt Cancer Center·Matthew C BiagioliRichard B Wilder
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·C RödelR Sauer
Aug 6, 2003·Critical Reviews in Oncology/hematology·Sana Al-Sukhun, Maha Hussain