Radiotherapy and androgen ablation for clinically localized high-risk prostate cancer

International Journal of Radiation Oncology, Biology, Physics
A PollackS Kopplin

Abstract

The response of patients with clinical stages T1-4 prostate cancer to radiotherapy is variable. A particularly poor prognostic group has been found to be comprised of those with pretreatment prostate specific antigen (PSA) levels above 30 ng/ml with any tumor grade, or PSA levels > 10 and < or = 30 with tumors grade 3 or 4. These patients have over an 80% actuarial risk of biochemical failure 3 years after definitive external beam radiotherapy. Thus, patients with these high-risk features require more aggressive therapy. During the last 3-4 years, the policy to treat such patients with radiotherapy and androgen ablation (XRT/HORM) was instituted. A retrospective comparison was made between high-risk patients treated with radiotherapy alone (XRT) vs. XRT/HORM. Between 1987 and 1991, there were 81 high-risk patients treated with XRT. There were 38 high-risk patients treated with XRT/HORM between 1990 and 1992. The median follow-up was 37 months for the XRT group and 22 months for the XRT/HORM group. No patient had clinical, radiographic, or pathologic evidence of lymph node involvement. The median dose to the prostate was 66 Gy for the XRT group and 68 Gy for the XRT/HORM group. The distributions of several potential prognostic f...Continue Reading

References

Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·R J AmdurR R Million
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsD H Hussey
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·M E SandsG K Zagars

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Citations

May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Nov 1, 1995·International Journal of Radiation Oncology, Biology, Physics·S P LankfordG K Zagars
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A PollackI I Rosen
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA G Ayala
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A PollackM E Sands
Jan 1, 1996·Urologic Oncology·C N Coleman, M A Stevenson
Dec 4, 1998·Urology·R Kirby
Mar 3, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A BylundA Bergh
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Khanh H NguyenAlan Pollack
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·S P LankfordG K Zagars
Jul 15, 1997·International Journal of Radiation Oncology, Biology, Physics·D L JoonA Pollack
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·P R AndersonG E Hanks
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·F A ViciniA A Martinez
Apr 21, 1998·Critical Reviews in Oncology/hematology·P Van ErpsL Denis
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·David C BeyerTheresa Thomas
Jun 1, 1996·Hematology/oncology Clinics of North America·P D GrimmD Clarke
Dec 3, 2014·Critical Reviews in Oncology/hematology·Rolando M D'AngelilloFilippo Alongi
Apr 22, 1999·BJU International·H H LeeM A Jewett
Apr 29, 1998·Seminars in Radiation Oncology·A Pollack, G K Zagars

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