PMID: 7993261Nov 1, 1994Paper

Radiotherapy and concurrent chemotherapy for oesophageal carcinoma

Australasian Radiology
R HuiI O'Rourke


This retrospective non-randomized study reports the outcome of 67 patients who received radical radiotherapy with or without two courses of concomitant chemotherapy using 5-fluorouracil and cis-platin at Westmead Hospital from 1985 to 1992. The overall median survival was 14.0 months, the actuarial 5-year survival was 18%, and median disease-free survival was 11.3 months. Forty-eight per cent of the 67 patients had complete endoscopic response and this resulted in a significantly improved survival for those patients. A pretreatment baseline Karnofsky performance > or = 80, and a baseline swallowing score > or = 80 also predicted for better survival. The development of acute toxicity did not predict the likelihood of developing chronic toxicity. The incidence of stricture formation (benign and malignant) requiring dilatation was 37%. There was no significant improvement in overall or disease-free survival, nor significant worsening of toxicity in the group of patients who received concurrent radiotherapy and chemotherapy compared with patients receiving radiotherapy alone.


Mar 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·M D LeslieE J Maher
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L R CoiaG E Hanks
Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L Taifu
Nov 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L R CoiaA Paul
May 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R J CaspersJ W Leer
Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·A ChanK Arthur
Feb 1, 1989·International Journal of Radiation Oncology, Biology, Physics·D R Sun
Jan 4, 1988·The Medical Journal of Australia·J W DenhamR Hecker
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·A HerskovicB White
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·A De PaoliM Arcicasa
May 2, 1988·The Medical Journal of Australia·I C O'RourkeA O Langlands
Mar 1, 1986·Journal of the Royal Society of Medicine·A Clark, L J Fallowfield
May 3, 1982·Clinical Radiology·G A NewaishyG R Kerr

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.