Radiotherapy Boost for the Dominant Intraprostatic Cancer Lesion-A Systematic Review and Meta-Analysis

Clinical Genitourinary Cancer
Finn Edler von EybenTimo Joensuu

Abstract

External beam radiotherapy (EBRT) for prostate cancer can be performed with a high dose of 86 Gy; however, one-tenth or more of the patients will develop recurrence. Prostate cancer is mainly multifocal, but a dominant intraprostatic lesion (DIL) is often the site of local recurrence after EBRT. We undertook a systematic review and meta-analysis to clarify whether functional imaging might identify the DIL and whether a RT boost to the DIL might be increased to an ultrahigh dose level of ≥ 90 Gy without increased toxicity. Of 62 selected studies, 13 reported the size of the DIL. The mean of the median DIL volumes was 2.4 cm(3) (95% confidence interval, 0.9-4.4 cm(3)). Eighteen diagnostic studies with 1205 patients evaluated the diagnostic accuracy using multiparametric magnetic resonance imaging for intraprostatic cancer lesions. Evaluating 14,654 prostate segments, the diagnostic accuracy was 77%. Eleven therapeutic studies with 988 patients reported a RT boost for the DIL. The summary boost dose for the DIL was a mean of 89 Gy in 5 studies using intensity modulated RT (calculated as the equivalent dose in 2-Gy fractions) and a mean of 141 Gy in 4 studies using a combination of EBRT and brachytherapy (P = .018, t test). In 1 th...Continue Reading

References

Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·B PickettM Roach
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerald E HanksUNKNOWN Radiation Therapy Oncology Group
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jinka R SathyaMark Levine
Jul 25, 2007·AJR. American Journal of Roentgenology·Masoom A HaiderJohn Trachtenberg
Dec 1, 2007·Journal of Magnetic Resonance Imaging : JMRI·Kengo YoshimitsuHiroshi Honda
Jan 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mack RoachMiljenko V Pilepich
Nov 26, 2009·AJR. American Journal of Roentgenology·Sophie F RichesNandita M deSouza
Dec 28, 2010·Journal of Clinical Epidemiology·Gordon H GuyattAndre Knottnerus
Apr 12, 2011·International Journal of Radiation Oncology, Biology, Physics·William W WongMichael C Roarke
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Feb 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Elnasif ArrayehFergus V Coakley
Feb 22, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter J HoskinLinda Bryant
Aug 21, 2012·The Journal of Urology·Baris TurkbeyPeter A Pinto
Nov 23, 2012·Journal of Magnetic Resonance Imaging : JMRI·Sofie IsebaertRaymond Oyen
Nov 29, 2012·Journal of Magnetic Resonance Imaging : JMRI·Andrea S KieransAndrew B Rosenkrantz
Jan 17, 2013·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Hyun KooBohyun Kim
Feb 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ralph A BundschuhBernd Joachim Krause
May 18, 2013·Journal of Magnetic Resonance Imaging : JMRI·Stephanie T ChangFergus V Coakley
Jun 25, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Glenn BaumanCynthia Ménard
Jun 26, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·L Van den BerghK Haustermans
Aug 27, 2013·AJR. American Journal of Roentgenology·Andrew B RosenkrantzFang-Ming Deng

❮ Previous
Next ❯

Citations

Oct 4, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·E OnjukkaI Syndikus
Aug 25, 2017·Physics in Medicine and Biology·Peter KuessTufve Nyholm
Sep 14, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jörg TamihardjaMichael Flentje
Aug 22, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rodrigo DelgadilloRadka Stoyanova
Dec 29, 2020·Frontiers in Oncology·Boris R ToccoAlison C Tree
Sep 10, 2021·Urologia·Francesco CelliniVincenzo Valentini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.