Radiotherapy effect on nano-mechanical properties and chemical composition of enamel and dentine

Archives of Oral Biology
Rachel ReedMary P Walker

Abstract

To understand radiotherapy-induced dental lesions characterized by enamel loss or delamination near the dentine-enamel junction (DEJ), this study evaluated enamel and dentine nano-mechanical properties and chemical composition before and after simulated oral cancer radiotherapy. Sections from seven non-carious third molars were exposed to 2 Gy fractions, 5 days/week for 7 weeks for a total of 70 Gy. Nanoindentation was used to evaluate Young's modulus, while Raman microspectroscopy was used to measure protein/mineral ratios, carbonate/phosphate ratios, and phosphate peak width. All measures were completed prior to and following radiation at the same four buccal and lingual sites 500 and 30 μm from the DEJ in enamel and dentine (E-500, E-30, D-30 and D-500). The elastic modulus of enamel and dentine was significantly increased (P ≤ 0.05) following radiation. Based on Raman spectroscopic analysis, there was a significant decrease in the protein to mineral ratio (2931/430 cm(-1)) following radiation at all sites tested except at D-500, while the carbonate to phosphate ratio (1070/960 cm(-1)) increased at E-30 and decreased at D-500. Finally, phosphate peak width as measured by FWHM at 960 cm(-1) significantly decreased at both D-3...Continue Reading

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Citations

Jul 9, 2016·National Journal of Maxillofacial Surgery·Nishtha GuptaBharti Devnani
Sep 9, 2016·Radiation Oncology·Eduardo Rodrigues FregnaniThais B Brandão
Apr 18, 2017·Archives of Oral Biology·Sandra Ribeiro de Barros da CunhaAna Cecília Corrêa Aranha
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Aug 5, 2017·Clinical Oral Investigations·Renata Borges RodriguesVeridiana Resende Novais
Dec 6, 2018·Clinical Oral Investigations·Rafael Resende de MirandaVeridiana Resende Novais
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Mar 26, 2021·Clinical Oral Investigations·Camila de Carvalho Almança LopesVeridiana Resende Novais
Sep 10, 2017·Dental Clinics of North America·Dwayne D ArolaRadi Masri

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