Radiotherapy for Active Thyroid Eye Disease

Ophthalmic Plastic and Reconstructive Surgery
Kyle J Godfrey, Michael Kazim

Abstract

To critically review the published literature on orbital radiotherapy as a treatment modality for thyroid eye disease (TED). A systematic review and analysis of the relevant published literature was performed. Thyroid eye disease is an autoimmune condition that is amenable to treatments that modulate the immune response, including orbital radiotherapy (ORT). Ideal candidates for ORT are patients in the early, active phase of TED with moderate to severe, or rapidly progressive, disease, including patients with significant motility deficits and compressive optic neuropathy. Patients with progressive strabismus may also benefit. Patients with mild or inactive disease will not benefit from ORT when compared with the natural history of the disease. Orbital radiotherapy should generally be used in conjunction with corticosteroid therapy, with response to corticosteroids demonstrating the immunomodulatory therapeutic potential of ORT. When treating TED-compressive optic neuropathy, ORT may help obviate the need for urgent surgical decompression, or postpone it until the stable, inactive phase of the disease. Orbital radiotherapy treatment doses should approach 20 Gy in most cases, but lower doses may be considered in younger patients ...Continue Reading

References

Sep 1, 1991·Ophthalmology·M KazimS Moore
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·I A PetersenS S Donaldson
Apr 1, 1990·Journal of Endocrinological Investigation·G KahalyS Bischoff
Jan 1, 1988·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·W M WiersingaL Koornneef
Nov 1, 1988·Ophthalmology·J M NeigelJ A Spinelli
Aug 1, 1973·The Journal of Clinical Endocrinology and Metabolism·S S DonaldsonJ P Kriss
Mar 1, 1994·Ophthalmic Plastic and Reconstructive Surgery·R WenzK Feldman
Jan 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Snijders-KeilholzJ J Broerse
Feb 1, 1997·Australian and New Zealand Journal of Ophthalmology·A A McNab
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·V BeckendorfE Luporsi
Aug 6, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K R Trott, F Kamprad
Feb 5, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J BroerseM H Seegenschmiedt
Oct 29, 2000·Experimental Gerontology·C Herskind, H P Rodemann
Nov 8, 2001·International Journal of Radiation Oncology, Biology, Physics·S D MarquezS S Donaldson
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Ulrich SchaeferNormann Willich
May 22, 2002·Ophthalmic Plastic and Reconstructive Surgery·George B Bartley, Colum A Gorman
May 22, 2002·Ophthalmic Plastic and Reconstructive Surgery·Michael Kazim
May 22, 2002·Ophthalmic Plastic and Reconstructive Surgery·Wilmar M Wiersinga
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Jürgen GerlingPeter Fells
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Claudio MarcocciAldo Pinchera
Jun 1, 1963·The American Journal of Medicine·J BROWNJ T DOWLING
Nov 1, 1964·The Journal of Clinical Endocrinology and Metabolism·N J SNYDERD H SOLOMON
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Mark F PrummelWilmar M Wiersinga
May 1, 1951·The Journal of Clinical Endocrinology and Metabolism·W H BEIERWALTES
Jan 1, 1952·The British Journal of Ophthalmology·K HERMANN
Dec 1, 1951·The British Journal of Radiology·A JONES
Aug 4, 2004·Ophthalmology·Iris M M J WakelkampWilmar M Wiersinga
Oct 30, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kristian T M JohnsonAnja K Eckstein
Apr 3, 2012·Revue de stomatologie et de chirurgie maxillo-faciale·N DumontL Guyot
Oct 6, 2012·The Journal of Clinical Endocrinology and Metabolism·L BartalenaUNKNOWN European Group on Graves' Orbitopathy
Jul 6, 2014·Ophthalmic Plastic and Reconstructive Surgery·Balaji Perumal, Dale R Meyer
Dec 24, 2014·Ophthalmic Plastic and Reconstructive Surgery·Courtney Y KauhAlon Kahana
Feb 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ji Won KimJin Sook Yoon

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Citations

May 29, 2020·American Journal of Ophthalmology Case Reports·Daniel J OzzelloBobby S Korn
Mar 21, 2021·International Ophthalmology Clinics·Jonathan Siktberg, Rachel K Sobel
Mar 25, 2021·ACS Sensors·Li JiangLiang Hu
Feb 27, 2021·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Paolo P LimoneMaurilio Deandrea
Sep 26, 2020·Ophthalmic Plastic and Reconstructive Surgery·Connie M SearsAndrea L Kossler
Jun 12, 2021·American Journal of Ophthalmology Case Reports·Connie M SearsAndrea L Kossler

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