PMID: 11325445Apr 28, 2001Paper

Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam?

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
P E HuberR Engenhart-Cabillic

Abstract

To compare retrospectively radiotherapy with neutrons, photons, and a photon/neutron mixed beam in patients with advanced adenoid cystic carcinoma of the head and neck. Local control, survival, distant failure, and complications were analyzed. Between 1983 and 1995, 75 patients with inoperable, recurrent, or incompletely resected adenoid cystic carcinoma of the head and neck received radiotherapy that consisted of either fast 14.1 MV DT neutrons (median dose 16 neutron Gy), linac-based photon irradiation (median dose 64 photon Gy), or both (median dose 8 neutron Gy and 32 photon Gy). Follow-up ranged from 1 to 160 months (median 51 months), and the surviving patients had a minimum follow-up of 3 years at the time of analysis. The actuarial 5-year local control was 75% for neutrons, and 32% for both mixed beam and photons (P = 0.015, log-rank). This advantage for neutrons in local control was not transferred to significant differences in survival (P > 0.1). The survival is dictated by the tumor diseases due to distant metastases occurring in 29 (39%) of the 75 patients. Positive lymph nodes were the only significant factor (P = 0.001) associated with the development of distant metastases although negative lymph nodes did not pre...Continue Reading

References

Jan 1, 1975·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·O M GuillamondeguiG H Fletcher
Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·B Zielke-Temme, M Wannenmacher
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·C C Wang, M Goodman
Nov 1, 1988·International Journal of Radiation Oncology, Biology, Physics·T W GriffinM H Maor
May 1, 1987·International Journal of Radiation Oncology, Biology, Physics·L MiglianicoP Wibault
Sep 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M Catterall, R D Errington
Oct 1, 1974·American Journal of Surgery·R H SpiroE W Strong
Feb 1, 1984·International Journal of Radiation Oncology, Biology, Physics·B VikramR H Spiro
Sep 1, 1983·International Journal of Radiation Oncology, Biology, Physics·D McNaneyM J Oswald
May 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J J BattermannH A van Peperzeel
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·M H MaorL W Davis
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A S GardenL J Peters
May 1, 1993·Current Opinion in Oncology
Jun 17, 1993·The New England Journal of Medicine·A Mashberg
Aug 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J G DouglasT W Griffin

❮ Previous
Next ❯

Citations

Feb 10, 2007·Current Oncology Reports·Joseph M Scianna, Guy J Petruzzelli
Apr 1, 2010·Indian Journal of Surgical Oncology·Vincent L M Vander PoortenPaul M J Clement
Dec 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Alen N CohenThomas C Calcaterra
May 14, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marc W MünterJürgen Debus
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Daniela Schulz-ErtnerJürgen Debus
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Rolf F BarthEinar K Rofstad
Jul 17, 2012·Japanese Journal of Clinical Oncology·Hirohiko Tsujii, Tadashi Kamada
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley
Apr 18, 2009·Current Opinion in Oncology·George E Laramore
Apr 7, 2011·Radiation Oncology·Alexandra D JensenMarc W Münter
Sep 16, 2011·Head & Neck Oncology·Kimberley HoYun Yen
Feb 8, 2013·Medical Physics·Jay BurmeisterMichael Snyder
Mar 24, 2011·The British Journal of Radiology·A D JensenJ Debus
Mar 20, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Cai-Neng CaoPing-Zhang Tang
Jan 10, 2012·American Journal of Otolaryngology·Christopher J BalamuckiWilliam M Mendenhall
May 31, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael SnyderJay Burmeister
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Shane LloydRoy H Decker
Dec 30, 2008·Current Problems in Surgery·Umamaheswar Duvvuri, Jeffrey N Myers
Nov 26, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-P JeannonR Simo
Apr 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Nathan BittnerJames G Douglas
Nov 22, 2007·International Journal of Radiation Oncology, Biology, Physics·Daniel R GomezNancy Y Lee
Oct 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Chris H J Terhaard
Apr 25, 2012·Asia-Pacific Journal of Clinical Oncology·Tao XuWei-Han Hu
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Chris H J TerhaardUNKNOWN Dutch Head and Neck Oncology Cooperative Group
Jun 9, 2004·International Journal of Oral and Maxillofacial Surgery·H KokemuellerJ-E Hausamen
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Allen M ChenKaren K Fu
Jun 20, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Katherine TriantafillidouDimitris Koufogiannis
Feb 24, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Eirik MalinenEinar Sagstuen
Jul 16, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P HalimiF Petit
Apr 6, 2013·Head & Neck·Vincent Vander PoortenAlfio Ferlito
Dec 10, 2014·Head & Neck·Patrick M DillonChristopher Y Thomas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.