PMID: 8960514Nov 1, 1996Paper

Radiotherapy for age-related macular degeneration: preliminary results of a potentially new treatment

International Journal of Radiation Oncology, Biology, Physics
A BersonJ L Bosworth

Abstract

Neovascular macular degeneration is the leading cause of severe blindness in North America today. Limited treatments are available for this disease process. A Phase I/II study was performed to determine the toxicity and efficacy of external beam radiotherapy in patients with age-related subfoveal neovascularization. Between March 1994 and June 1995, 52 patients with a mean age of 80 (60-92) were enrolled. These patients were either not eligible or were poor candidates for laser photocoagulation, primarily because of the subfoveal location of the neovascularization. Initial visual acuities ranged from 20 out of 32 to finger counting at 3 feet. All patients underwent fluorescein angiographic evaluation and documentation of their neovascular disease prior to irradiation. Patients were treated with a single lateral 4- or 6-MV photon beam, to a dose of 14-15 Gy in eight fractions over 10 days. The field size averaged 5 x 3 cm. No significant acute morbidity was noted. All patients underwent ophthalmic examinations and repeat angiography at 1 and 3 months posttreatment and then at 3-month intervals. With a mean follow-up of 7 months (3-18 months), 41 patients (79%) are within two lines of their pretreatment visual acuity. On angiogra...Continue Reading

References

Jan 1, 1986·Advances in Enzyme Regulation·P HerrlichM Schorpp
May 11, 1989·La Revue du praticien·G Soubrane, G Coscas
May 1, 1983·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
May 1, 1980·Survey of Ophthalmology·D E KreugerL R Maunder
Oct 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G J BerginkR W van der Maazen
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Feb 1, 1994·Optometry and Vision Science : Official Publication of the American Academy of Optometry·R W Young
May 1, 1993·The British Journal of Ophthalmology·U ChakravarthyD B Archer
Jan 15, 1993·American Journal of Epidemiology·R KleinD L DeMets

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Citations

Nov 18, 2000·American Journal of Ophthalmology·H Kobayashi, K Kobayashi
May 20, 1999·American Journal of Ophthalmology·D H CharS Kroll
Oct 31, 1998·Harvard Women's Health Watch
Dec 22, 1999·Ophthalmology·R F SpaideJ A Sorenson
Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Stephan GrippChristoph Althaus
Nov 1, 1996·International Journal of Radiation Oncology, Biology, Physics·L W Brady
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·M AkmansuM Or
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·V Vinh-HungG Storme
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·D E RoosW J Newnham
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·S StaarK Heimann
Jun 30, 2000·Clinical Eye and Vision Care·T J Stokkermans
Jun 30, 2000·The British Journal of Ophthalmology·N EterM Spitznas
Jun 30, 2000·The British Journal of Ophthalmology·H Kobayashi, K Kobayashi
Dec 9, 2003·The British Journal of Ophthalmology·P T FingerA Szechter
Oct 20, 2007·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Guy Donati
Apr 13, 2002·Drugs & Aging·Morten la CourMogens Holst Nissen
Mar 17, 2010·Medical Physics·Michael GertnerDarius M Moshfeghi
Sep 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Amar U KishanPercy Lee
Oct 1, 2003·Clinical & Experimental Ophthalmology·Claire Y Hooper, Robyn H Guymer
Jan 27, 1998·Ophthalmology·R F SpaideD Abramson
May 19, 2000·The British Journal of Radiology·U Chakravarthy, G MacKenzie
Aug 13, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Andrew A MoshfeghiDarius M Moshfeghi
Jun 10, 2000·Seminars in Ophthalmology·O Gelisken, B Yazici
Jan 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·U PrettenhoferA Hackl
Mar 1, 2016·International Journal of Particle Therapy·Stephanie R RiceMinesh P Mehta
Oct 8, 1998·Survey of Ophthalmology·T A CiullaA Harris
Jun 19, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A MazalJ C Rosenwald

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