Radiotherapy for extramedullary plasmacytoma of the head and neck

International Journal of Radiation Oncology, Biology, Physics
Kimberly M CreachRobert A Kyle

Abstract

To define the effectiveness of radiotherapy in the treatment of patients with extramedullary plasmacytoma of the head and neck (EMPHN). We searched the Mayo Clinic Rochester Department of Radiation Oncology electronic Tumor Registry and identified 18 consecutive patients with a diagnosis of solitary EMPHN. Sixteen patients were treated with radiotherapy at initial diagnosis and 2 received salvage radiotherapy for local failure after surgery. Median dose administered was 50.4 Gy. Median follow-up was 6.8 years. One patient (6%) developed a marginal recurrence 12 months after treatment. Six patients (33%) developed multiple myeloma (2 patients) or plasmacytomas at distant sites (4 patients) at a median of 3.1 years after diagnosis (range, 0.02 to 9.6 years). Median and 5- and 10-year overall survival rates from the date of diagnosis are 12.5 years, 88%, and 55%, respectively. Two patients (11%) developed a radiation-induced malignancy at 6.5 and 6.9 years after treatment. Radiotherapy provides excellent local and regional tumor control and survival in patients with EMPHN. To the best of our knowledge, this is the first report of presumed radiation-induced malignancy in this patient population.

References

Aug 1, 1991·The Journal of Laryngology and Otology·P D Kerr, J C Dort
Jul 1, 1990·Archives of Otolaryngology--head & Neck Surgery·J RubinL Barnes
Nov 1, 1980·International Journal of Radiation Oncology, Biology, Physics·C M MendenhallR R Million
May 1, 1997·The British Journal of Radiology·R JyothirmayiB Rajan
May 14, 1998·The Journal of Laryngology and Otology·J WelshD J Lee
May 21, 1999·The Annals of Otology, Rhinology, and Laryngology·M A HotzJ N Munck
Dec 2, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R H LiebrossR Alexanian
May 2, 2000·The Journal of Laryngology and Otology·H HidakaT Takasaka
Oct 19, 2000·Acta Ophthalmologica Scandinavica·A Uceda-MontañésJ Cuevas
Mar 3, 2001·American Journal of Ophthalmology·S G HonavarH Ehya
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·R W TsangA K Stewart
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Primoz StrojanAnton Munda
Sep 17, 2002·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Chris J WebbTim Helliwell
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Eric J Hall, Cheng-Shie Wuu
Sep 27, 2003·The British Journal of Radiology·V J MichalakiK J Harrington
Apr 20, 2005·Internal Medicine Journal·M W ChaoK H Liew
Dec 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Laetitia Tournier-RangeardDidier Peiffert
Jan 13, 2006·Auris, Nasus, Larynx·Takahiro NakashimaAtsushi Haruta

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Citations

Oct 12, 2011·Pituitary·Rene Joukhadar, Ken Chiu
Feb 13, 2009·Medical Oncology·Hanno HuwerWerner Püschel
Dec 3, 2010·Surgical Neurology International·Lola B ChamblessKyle D Weaver
Oct 2, 2013·Iranian Red Crescent Medical Journal·Mohamad Javad AshrafBita Valibeigi
Oct 25, 2013·Clinical Nuclear Medicine·Yazan Z AlabedJerome Laufer
Jan 16, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Michael WebbVernon Louw
Jun 16, 2012·Journal of Medical Imaging and Radiation Oncology·Jennifer TanMichael P Mac Manus
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Ryohei SasakiSyogo Yamada
Apr 12, 2016·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Diana VladSilviu Albu
Nov 12, 2016·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Santhosh Kumar NochikattilShaji Thomas
Jun 15, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ming LuoJing Cheng
Mar 14, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Daniel Gerry, Eric J Lentsch
May 30, 2014·Der Radiologe·M C Schmaus, D Neuhof
Jan 29, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Ki-Uk NamJongrak Hong
Jan 6, 2018·BMJ Case Reports·Sehrish AbrarAhmed Nadeem Abbasi
Mar 28, 2019·American Journal of Hematology·Joan HowNathan T Connell
Feb 22, 2011·Annals of Hematology·Sonja KrauseDirk Neuhof
Apr 11, 2012·Head & Neck·Geoffrey A NeunerWilliam F Regine
Jun 2, 2018·Journal of Investigative Medicine High Impact Case Reports·Tagore SunkaraGhulamullah Shahzad
Aug 11, 2020·Case Reports in Hematology·Parikshit Padhi, Radwa El-Behery
Oct 15, 2010·Proceedings·Robert Arthur Kyle, William Clifford Roberts
Apr 14, 2018·Case Reports in Hematology·Nieves GascónJosé Fermín Pérez-Regadera
May 23, 2019·Journal of Medical Case Reports·Leonard Naymagon, Maher Abdul-Hay
Apr 11, 2019·Ear, Nose, & Throat Journal·Nikolina ČunovićVladimir Bedeković
Nov 30, 2019·Leukemia·Manisha BhutaniSaad Z Usmani
Nov 26, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Siow Ping LoongCheng Ai Ong
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Qi-Wen LiYu-Jing Zhang
Dec 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Shaji K KumarRashmi Kumar
Jul 3, 2021·International Journal of Molecular Sciences·Shiva Kumar Reddy Mukkamalla, Dhatri Malipeddi
Mar 18, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

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