Radiotherapy for Hepatocellular Carcinoma Results in Comparable Survival to Radiofrequency Ablation: A Propensity Score Analysis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Koji HaraKazushi Numata

Abstract

Potentially curative treatments for early-stage hepatocellular carcinoma (HCC) have drawbacks and contraindications. Recently, radiotherapy has achieved good outcomes. We compared the outcomes of radiotherapy and radiofrequency ablation (RFA) for early-stage HCC. Consecutive patients with ≤3 early-stage HCC lesions and tumor diameters ≤3 cm treated with RFA or radiotherapy were reviewed. RFA was the first choice for HCC unsuitable for surgery. Otherwise, stereotactic body radiotherapy in five fractions was mainly performed. For HCC adjacent to the gastrointestinal tract, radiotherapy with mild hypofractionation was performed. Propensity score matching was performed to reduce the selection bias between the RFA and radiotherapy groups. Between 2012 and 2016, a total of 231 patients with 474 tumors and 143 patients with 221 tumors were eligible and were treated with RFA and radiotherapy, respectively. In an unmatched comparison, the 3-year local recurrence rate was significantly lower for radiotherapy than for RFA (5.3%; 95% confidence interval [CI], 2.7-9.2; versus 12.9%, 95% CI, 9.9-16.2) (P < 0.01). A propensity score matching analysis of 106 patients in each group successfully matched the two treatment groups with regard to Ba...Continue Reading

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Citations

Jul 8, 2020·Journal of Gastroenterology and Hepatology·Mihir D ShankerDavid I Pryor
Nov 13, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo PrawiraHung Huynh
Dec 1, 2020·International Journal of Radiation Biology·Chai Hong RimHakyoung Kim
Oct 28, 2020·BMJ : British Medical Journal·Ju Dong Yang, Julie K Heimbach
Jan 6, 2021·Journal of Cancer Research and Clinical Oncology·Luca BoldriniVincenzo Valentini
Feb 17, 2021·Expert Review of Anticancer Therapy·Antonio FacciorussoChristian Cotsoglou
Nov 18, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuichiro TsurugaiYousuke Aoki
Apr 20, 2021·Frontiers in Oncology·Luca BoldriniLaura Dawson
Jun 8, 2021·World Journal of Gastroenterology : WJG·Liang-Cheng ChenMoon-Sing Lee
Jun 25, 2021·Journal of Hepatocellular Carcinoma·Ashwathy S Mathew, Laura A Dawson
Apr 16, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takahisa EriguchiNobuyuki Horita
Aug 5, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenya Kamimura, Shuji Terai
Sep 14, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Tung-Hung SuJia-Horng Kao

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