PMID: 12242114Sep 21, 2002Paper

Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Normand LaperriereCancer Care Ontario Practice Guidelines Initiative Neuro-Oncology Disease Site Group

Abstract

A systematic review was conducted to develop guidelines for radiotherapy in adult patients with newly diagnosed malignant glioma. MEDLINE, CANCERLIT, the Cochrane Library, and relevant conference proceedings were searched to identify randomized trials and meta-analyses. Pooling of six randomized trials detected a significant survival benefit favouring post-operative radiotherapy compared with no radiotherapy (risk ratio, 0.81; 95% confidence interval, 0.74 to 0.88, P<0.00001). Two randomized trials demonstrated no significant difference in survival rates for whole brain radiation versus more local fields that encompass the enhancing primary plus a 2 cm margin. A randomized trial detected a small improvement in survival with 60 Gy in 30 fractions over 45 Gy in 20 fractions. Radiation dose intensification and radiation sensitizer approaches have not demonstrated superior survival rates compared with conventionally fractionated doses of 50-60 Gy. Post-operative external beam radiotherapy is recommended as standard therapy for patients with malignant glioma. The high-dose volume should incorporate the enhancing tumour plus a limited margin (e.g. 2 cm) for the planning target volume, and the total dose delivered should be in the ran...Continue Reading

References

Jun 17, 1976·The New England Journal of Medicine·R UrtasunC Fryer
Jul 1, 1976·International Journal of Radiation Oncology, Biology, Physics·W J Simpson, M E Platts
Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·A P Andersen
Jan 1, 1991·Journal of Neurosurgery·T KayamaY Sakurai
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·K E WallnerM G Malkin
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·G E LaramoreJ Saxton
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·L S ConstineP Rubin
Nov 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C M LudgateG B Goodman
Jan 1, 1987·Journal of Neurosurgery·S A Leibel, G E Sheline
May 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H KeimK R Trott
Jan 23, 1988·British Medical Journal·C L Hall
Jul 1, 1987·International Journal of Radiation Oncology, Biology, Physics·W J CurranD F Nelson
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1985·Journal of Neuro-oncology·D F NelsonT F Pajak
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·D S FultonE Johnson
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·B StadlerT Szepesi
Sep 1, 1980·Neurology·F H Hochberg, A Pruitt
Dec 1, 1983·American Journal of Clinical Oncology·T W GriffinJ Nelson
Nov 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R ThomasM Brada
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D GannettA Hamilton
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J M BuattiW M Mendenhall
Apr 1, 1995·Journal of Neurosurgery·J E MasciopintoB S Rhode
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J S LoefflerE Alexander
Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·R RamplingP Workman
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·G S BaumanJ G Cairncross
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·B J SlotmanA B Karim
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·D A LarsonT Shibazaki
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·J M FordN M Bleehen

❮ Previous
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Citations

Sep 7, 2007·Acta Neuropathologica·An ClaesPieter Wesseling
Oct 11, 2011·Journal of Neuro-oncology·Matthew KoshyBridget J McCarthy
Oct 13, 2006·Current Treatment Options in Oncology·Lyndon Kim, Michael Glantz
Feb 9, 2006·Current Oncology Reports·René-Olivier Mirimanoff
May 12, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Corrie A M MarijnenEd M Noordijk
May 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kazuhiko OgawaSadayuki Murayama
May 30, 2012·Nature Reviews. Clinical Oncology·Chris JonesDarren Hargrave
Apr 7, 2010·Neuro-oncology·Luc BauchetUNKNOWN Association des Neuro-Oncologues d'Expression Française (ANOCEF)
Sep 4, 2003·The Cancer Journal·Ian F Parney, Susan M Chang
Nov 5, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Alan JacksonSamantha Mills
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stuart A GrossmanUNKNOWN NABTT CNS Consortium
Nov 10, 2010·Journal of Experimental & Clinical Cancer Research : CR·Sandrine Vinchon-PetitPhilippe Menei
Nov 13, 2007·Neuro-oncology·Graziella FilippiniUNKNOWN Brain Cancer Register of the Fondazione IRCCS (Istituto Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo
Sep 28, 2013·PloS One·Irene Rodríguez-HernándezRogelio González-Sarmiento
Nov 28, 2012·Journal of Neurosurgery·Shota TanakaIan F Parney
Apr 17, 2007·Journal of Neurosurgery·Justin S SmithSusan M Chang
Jun 28, 2007·Current Oncology·W P MasonUNKNOWN Canadian GBM Recommendations Committee
Feb 10, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Anette StorsteinRené van Helvoirt
Dec 12, 2013·Chinese Journal of Cancer·Salvador VillàSílvia Comas
Jan 2, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mario AmmiratiJohn Grecula
Jan 18, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ryan C WidauNikolai N Khodarev
Jul 25, 2014·Mathematical Biosciences·J R BrancoPaula de Oliveira
Sep 1, 2014·Seminars in Oncology·Aidnag Z Diaz, Mehee Choi
Sep 1, 2014·Seminars in Oncology·Linda DirvenMartin J B Taphoorn
Aug 1, 2014·The Lancet Oncology·Michael WellerUNKNOWN European Association for Neuro-Oncology (EANO) Task Force on Malignant Glioma
Sep 16, 2014·Seminars in Radiation Oncology·Shannon FoghPenny K Sneed
Jan 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Chad G RusthovenBrian D Kavanagh

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