Radiotherapy improves serum fatty acids and lipid profile in breast cancer

Lipids in Health and Disease
Sana ShaikhNaila Tabassum

Abstract

Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer. In this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile. Among serum free and total fatty acids the major saturated fatty acids (SFAs) in serum lipids of breast cancer patients (pre and post treated) were stearic acid (18:0) and palmitic acid (16:0). These fatty acids contributed about 35-50% of total fatty acids. The decreased concentrations of linoleic acid (C18:2) and arachidonic acid (C20:4) with a lower ratio of C18:2/C18:1 was found in pretreated breast cancer patients as compared to controls. The n-3/n-6 ratio of breast cancer patients was decreased before treatment but it was 35% increased after treatment. In addition, plasma activity of D6 desaturase was increased in the breast cancer patients, while the activity o...Continue Reading

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Citations

Jun 12, 2019·Lipids in Health and Disease·Xuefeng GuanYu Ding
Jul 28, 2019·International Journal of Molecular Sciences·Matteo Rossi Sebastiano, Georgia Konstantinidou
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Zhu-Hui YuanJun-Jie Wang

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