PMID: 7546821Jan 1, 1995Paper

Radiotherapy in addition to radical surgery in rectal cancer

Acta Oncologica
B GlimeliusL Påhlman

Abstract

In order to lower unacceptably high local failure rates after surgery reported as curative for rectal cancer, perioperative radiotherapy has been extensively investigated. The collected information from a number of controlled trials indicates that the proportion of local recurrences is reduced to less than half when radiotherapy at moderately high doses is given preoperatively. This reduction in local failure rates is not seen after postoperative radiotherapy, even if higher doses have been used. Possibly, there is also a slight positive influence on survival from preoperative radiotherapy. Improved survival has been seen also in trials using postoperative radiotherapy, but then only when combined with chemotherapy. With proper dose planning, sufficiently high doses can be given preoperatively with little if any increase in postoperative mortality. Thus, although published knowledge is still rather limited, a properly planned preoperative radiotherapy seems to inflict small bowel and other complication rates, that are less than when radiotherapy of similar efficacy against the tumour is given postoperatively.

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Citations

Apr 17, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Anna GasinskaTeresa Kowalska
Feb 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G J FrykholmB Glimelius
Dec 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·U IsacssonB Glimelius
May 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W GrafB Glimelius
Apr 14, 1999·The British Journal of Surgery·M DahlbergL Påhlman
Apr 3, 1997·The New England Journal of Medicine·UNKNOWN Swedish Rectal Cancer TrialN Wilking
Apr 21, 2007·Digestive Surgery·Masato Kusunoki, Yasuhiro Inoue
Jun 1, 1996·The British Journal of Surgery·B GlimeliusL Påhlman
Jun 2, 1998·The British Journal of Surgery·M DahlbergB Glimelius

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