Radiotherapy in early-stage Dupuytren's contracture. Long-term results after 13 years.

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Nicolas BetzL Keilholz

Abstract

In early-stage Dupuytren's contracture, radiotherapy is applied to prevent disease progression. Long-term outcome and late toxicity of the treatment were evaluated in a retrospective analysis. Between 12/1982 and 02/2006, 135 patients (208 hands) were irradiated with orthovoltage (120 kV; 20 mA; 4-mm Al filter), in two courses with five daily fractions of 3.0 Gy to a total dose of 30 Gy; separated by a 6- to 8-week interval. The extent of disease was described according to a modified classification of Tubiana et al. Long-term outcome was analyzed at last follow-up between 02/2008 and 05/2008 with a median follow-up of 13 years (range, 2-25 years). Late treatment toxicity and objective reduction of symptoms as change in stage and numbers of nodules and cords were evaluated and used as evidence to assess treatment response. According to the individual stages, 123 cases (59%) remained stable, 20 (10%) improved, and 65 (31%) progressed. In stage N 87% and in stage N/I 70% remained stable or even regressed. In more advanced stages, the rate of disease progression increased to 62% (stage I) or 86% (stage II). 66% of the patients showed a long-term relief of symptoms (i.e., burning sensations, itching and scratching, pressure and tens...Continue Reading

References

Aug 1, 1978·The Journal of Dermatologic Surgery and Oncology·S LukacsH Goldschmidt
Feb 1, 1990·The Biochemical Journal·G A MurrellL Bromley
Jan 1, 1986·Annales De Chirurgie De La Main : Organe Officiel Des Sociétés De Chirurgie De La Main·R Tubiana
Nov 1, 1996·International Journal of Radiation Oncology, Biology, Physics·L KeilholzR Sauer
Jan 1, 1997·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·L KeilholzR Sauer
Dec 20, 2000·The Journal of Hand Surgery·L D Ketchum, T K Donahue
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M H SeegenschmiedtF Guntrum
Jan 5, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·B AdamietzR Sauer
Jun 28, 2002·Plastic and Reconstructive Surgery·Kurtis E MoyerH Paul Ehrlich
Dec 4, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michael Heinrich Seegenschmiedt, Mared Attassi
Dec 13, 2005·Techniques in Hand & Upper Extremity Surgery·Iain T H Au-YongRobert E Page
Feb 18, 2006·BMJ : British Medical Journal·W A TownleyA O Grobbelaar
Aug 10, 2006·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Klaus-Rüdiger Trott, Friedrich Kamprad
Jan 18, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Reinhard HeydNikolaos Zamboglou
Feb 6, 2007·Clinics in Dermatology·David T Robles, Daniel Berg
May 10, 2007·International Journal of Radiation Biology·F RödelG Hildebrandt
May 11, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan Willem LeerHeinrich Seegenschmiedt
Jul 5, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jakob Roth, Aurélien Emmanuel Martinez
Jan 12, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Franz RödelHorst Ulrich Beuscher
Apr 10, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marcin SumilaGuenther Gruber
Apr 23, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Boris AdamietzLudwig Keilholz
Jul 9, 2008·Acta Oncologica·Luca IncrocciHeinrich M Seegenschmiedt
Jul 23, 2008·BMC Musculoskeletal Disorders·Debbie Larson, Christina Jerosch-Herold
Oct 30, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christof Schäfer, Christian Koller

❮ Previous
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Citations

Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Liaquat S VerjeeJagdeep Nanchahal
Aug 31, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Reinhard HeydUNKNOWN German Cooperative Group on Radiotherapy Benign Diseases (GCG-BD)
Feb 22, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Reinhard HeydNikolaos Zamboglou
Aug 22, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M ArenasJ Panés
Jan 16, 2014·Hand : Official Journal of the American Association for Hand Surgery·Heather A McMahonA Lee Osterman
Mar 11, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M Heinrich SeegenschmiedtUNKNOWN German Cooperative Group on Radiotherapy of Benign Diseases (GCG-BD)
May 9, 2015·The British Journal of Radiology·M H SeegenschmiedtUNKNOWN German Cooperative Group on Radiotherapy for Non-malignant Diseases (GCG-BD)
May 3, 2015·Hand Clinics·Kevin CheungTamara D Rozental
Feb 1, 2011·Medical Hypotheses·Karsten KnoblochPeter M Vogt
Sep 3, 2013·IEEE Transactions on Bio-medical Engineering·Marcel RufLorenz-Peter Schmidt
Apr 16, 2014·Journal of Medical Imaging and Radiation Oncology·Solveig Grenfell, Martin Borg
Dec 28, 2016·Plastic and Reconstructive Surgery·Keith A DenklerScott L Hansen
Sep 12, 2015·The Journal of Hand Surgery, European Volume·R WadeA Figus
Nov 13, 2018·Hand : Official Journal of the American Association for Hand Surgery·Kalila SteenSteven McCabe
Jun 28, 2011·Plastic and Reconstructive Surgery·Steven E R HoviusRoger K Khouri
Nov 10, 2010·Nature Reviews. Rheumatology·Barbara Shih, Ardeshir Bayat
Dec 3, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Young-Mi KangSeong-Hwan Moon
Sep 10, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M ZirbsB Eberlein
Apr 30, 2014·Plastic and Reconstructive Surgery·Charles Eaton
May 12, 2017·The Journal of Hand Surgery, European Volume·M KadhumA Fleming
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·B Eberlein, T Biedermann
May 19, 2017·Frontiers in Immunology·Franz RödelStephanie Hehlgans
Sep 8, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·I Frank CiernikJochen Winter
Oct 28, 2021·Deutsches Ärzteblatt International·Mike RuettermannPaul M N Werker

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