Radiotherapy in the treatment of gastrointestinal stromal tumor.

Rare Tumors
Christin A KnowltonRebecca C Heintzelman

Abstract

Gastrointestinal stromal tumors (GISTs) are uncommon mesenchymal tumors of the gastrointestinal tract. Up to one-third of GISTs are malignant with a high rate of metastasis. Surgical resection is the mainstay of care for patients with resectable disease. Imatinib mesylate, a selective tyrosine kinase inhibitor, is the current standard of care for GISTs that cannot be completely resected or in cases of metastatic GIST. Although often overlooked, radiation therapy is a viable option for select patients with GIST. We report the case of a patient with unresectable GIST who was treated with local radiotherapy and achieved long-term response. We also present a review of the literature regarding the use of radiotherapy in the treatment of GIST. GIST has been shown to be a radiosensitive tumor. Radiotherapy can offer long-term local control and should be considered in the adjuvant or palliative setting. The role of radiotherapy delivered concurrently with imatinib in the treatment of GIST may warrant further investigation.

References

Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
Apr 3, 2001·Digestive Diseases and Sciences·J PollockJ Williams
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Dec 7, 2007·Clinics in Plastic Surgery·Dennis J Hurwitz, Tim Neavin

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Citations

Apr 5, 2012·Nature Reviews. Clinical Oncology·D Ross Camidge, Robert C Doebele
Apr 30, 2013·Lancet·Heikki JoensuuChristopher L Corless
Dec 10, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S HeymannL-M Dourthe
Nov 15, 2014·Future Oncology·Maristella SaponaraGuido Biasco
Jul 22, 2016·Rare Tumors·Jacob HabboushRobert Miller
Jan 18, 2018·Chinese Medical Journal·Emine Elif Ozkan
Mar 12, 2015·World Journal of Gastroenterology : WJG·Takeshi GohongiTakesaburo Ogata

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Methods Mentioned

BETA
surgical resection
biopsy

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