Radiotherapy-Induced Skin Reactions Induce Fibrosis Mediated by TGF-β1 Cytokine

Dose-response : a Publication of International Hormesis Society
Cherley Borba Vieira de AndradeCarlos Eduardo Veloso de Almeida

Abstract

This study aimed to investigate radiation-induced lesions on the skin in an experimental animal model. Methods and Materials: Cutaneous wounds were induced in Wistar rats by 4 MeV energy electron beam irradiation, using a dose rate of 240 cGy/min, for 3 different doses (10 Gy, 40 Gy, and 60 Gy). The skin was observed 5, 10, and 25 days (D) after ionizing radiation exposition. Infiltrate inflammatory process was observed in D5 and D10, for the 40 Gy and 60 Gy groups, and a progressive increase of transforming growth factor β1 is associated with this process. It could also be noted a mischaracterization of collagen fibers at the high-dose groups. It was observed that the lesions caused by ionizing radiation in rats were very similar to radiodermatitis in patients under radiotherapy treatment. This study is important to develop strategies to prevent radiation-induced skin reactions.

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Citations

May 16, 2020·American Journal of Clinical Dermatology·Kurt A AshackLaura Ashack
Dec 29, 2019·Plastic and Reconstructive Surgery·Jessica L TruongEva A Turley
Jun 6, 2020·European Radiology Experimental·Matheus da Silva SantinJosé Rosa Gomes
Dec 1, 2020·Clinical Orthopaedics and Related Research·Itai GansCarol D Morris
Mar 24, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Andrea MantuanoCarlos E de Almeida
Jun 11, 2020·Aesthetic Surgery Journal·Marwan H AbboudNicolas M Abboud

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Methods Mentioned

BETA
light microscopy
light
scanning electron microscopy

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