Abstract
Radiotherapy plays an important role in the treatment of basal cell carcinoma of the face and head and achieves cure rates of 92-96 %. Different fractionation concepts of radiotherapy have been described. This study investigates the efficacy, as well as acute and chronic toxicity, of a slightly hypo-fractionated radiotherapy schedule. 85 patients with 104 tumors underwent radiotherapy for basal cell carcinoma of the face and head. The radiotherapy schedule was 5 x 3 Gray/week up to a total dose of 57 Gray in 95 % of patients. Acute and late radiotherapy toxicity and cosmetic outcome were evaluated in long-term follow-up. No recurrence was observed. In 87 % of tumors, only low acute toxicity occurred at the end of radiotherapy. Late toxicity, if observed, was low in most patients. "Excellent" or "good" cosmesis was achieved in 94 % of tumors at last follow-up. Our radiotherapy schedule achieves a very high local control rate and very good cosmetic and functional results. This fractionation can be recommended as a standardized radiotherapy treatment for basal cell carcinoma of the face and head.
References
Jul 1, 1992·The Journal of Dermatologic Surgery and Oncology·M K SilvermanM J Levenstein
Nov 15, 1991·Cancer·R B WilderD S Shimm
Sep 1, 1990·Clinical Oncology : a Journal of the Royal College of Radiologists·M A Ashby, L McEwan
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·R D LovettD M Garcia
Mar 1, 1989·The Journal of Dermatologic Surgery and Oncology·D E RoweC L Day
Feb 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J S AbbatucciJ C Lozier
Apr 1, 1984·International Journal of Radiation Oncology, Biology, Physics·P J FitzpatrickD G Payne
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J J PavyH Bartelink
Nov 28, 1997·Postgraduate Medical Journal·J T Lear, A G Smith
Jun 14, 2000·Plastic and Reconstructive Surgery·J Y PetitM Rietjens
Jun 12, 2001·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M H SeegenschmiedtT Olschewski
Jul 12, 2001·Otolaryngologic Clinics of North America·J K Padgett, J D Hendrix
Mar 18, 2003·Seminars in Oncology Nursing·Nancy Vargo
Jul 19, 2003·The Australasian Journal of Dermatology·Michael Veness, Shawn Richards
Dec 12, 2003·Cancer·Beate ZagrodnikReinhard Dummer
Citations
Nov 22, 2015·Journal of the American Academy of Dermatology·Riccardo PampenaCaterina Longo
Oct 10, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Björn SchulzePanagiotis Balermpas
Oct 12, 2010·Brachytherapy·Maria MaroñasRodrigo Muelas
Mar 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marjan van HezewijkCorrie A M Marijnen
Dec 12, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·K-W SchulteL Suter
Jul 22, 2014·The British Journal of Dermatology·M ChoT C S Woo
Sep 15, 2015·Current Problems in Cancer·Tobin Strom, Louis B Harrison
Sep 27, 2014·Geriatrics & Gerontology International·Nam P NguyenUNKNOWN International Geriatric Radiotherapy Group
May 22, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·L Schmitz, T Dirschka
Mar 11, 2018·Journal of Medical Imaging and Radiation Oncology·Dakshika A Gunaratne, Michael J Veness
Feb 15, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Berenice M LangStephan Grabbe
Feb 15, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Berenice M LangStephan Grabbe
Jan 11, 2020·Radiation Oncology Journal·Jae Wang KimYoung Suk Kim
Aug 25, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Tobin J StromLouis B Harrison
May 9, 2015·Expert Review of Anticancer Therapy·Yi RongJose G Bazan
Aug 17, 2019·Pharmacology & Therapeutics·Asim EjazPeter J Rubin