Radiotherapy of epidermoid anal canal cancer

The British Journal of Radiology
W Dobrowsky

Abstract

Forty-eight patients with anal canal cancers were treated with surgery and irradiation or irradiation alone during the period 1970-1982. All cases were treated by external megavoltage equipment. The overall 5-year survival was 50%, and the local recurrence rate 33%. According to the therapy, four major groups were analysed: radical surgery followed by post-operative irradiation (5-year survival 43%, local recurrence rate 38%), incomplete major surgery and post-operative irradiation with very inferior prognosis (none of the patients surviving beyond 52 months). Two groups of patients had sphincter-saving procedures: local surgery followed by irradiation (5-year survival 78%, local recurrence rate 22%) and primary irradiation (5-year survival 57%, local recurrence rate 14%). Lymph node positive patients showed a median survival of 24.5 months against 52 months in N0 cases (5-year survival 21% against 50%). Side-effects of radiotherapy were transient and mild, and no late severe sequelae were seen. The data indicate that post-operative external radiotherapy seems insufficient and unable to decrease the local recurrence rate, especially when surgery is incomplete. Both spincter-saving surgery and radiotherapy, as well as primary ir...Continue Reading

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Citations

Sep 1, 1993·International Journal of Radiation Oncology, Biology, Physics·C SvenssonB Friberg
May 27, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joachim WidderRichard Pötter
Jun 18, 2002·The Oncologist·Natia EsiashviliRichard H Matthews
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·C SvenssonB Glimelius

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