PMID: 11917285Mar 28, 2002Paper

Radiotherapy or chemotherapy followed by radiotherapy with or without amifostine in locally advanced lung cancer

Seminars in Radiation Oncology
Dosia Antonadou

Abstract

Radiotherapy (RT) or radiochemotherapy is the treatment of choice for patients with medically or technically inoperable non-small cell lung cancer (NSCLC) localized to the primary site and regional lymph nodes. Radiation-induced damage has been recognized as a major complication in thoracic RT. The use of concurrent chemoradiation has been associated with an increase in acute and late toxicity. Amifostine (Ethyol) is an effective cytoprotective agent and also may have a role in protecting healthy lung tissue during radiation treatment. The purpose of these 2 clinical trials was to investigate whether daily pretreatment with amifostine could reduce the incidence of esophagitis, and acute and late lung toxicity without affecting the antitumor efficacy of the treatment. The first was a phase III randomized trial of 146 patients with locally advanced lung cancer. All patients received conventional RT to a total of 55 to 60 Gy, and they were assigned randomly to pretreatment with 340 mg/m(2) of amifostine (A). Acute and late toxicities were graded according to the Radiation Therapy Oncology Group (RTOG) grading system from grades 0 to 4. Ninety-seven patients were evaluated 2 months post-RT for the incidence of pneumonitis; 43% (23 ...Continue Reading

Citations

Apr 6, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rene-Jean BensadounDorothy Keefe
Jul 31, 2012·Journal of Cancer Research and Clinical Oncology·Xiao-Jing ZhangZheng-Tang Chen
Oct 6, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Donald P BraunEdgar D Staren
Nov 2, 2019·Hematology/oncology Clinics of North America·Deborah E Citrin
Oct 31, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mitchell MachtayMelpo Christofidou-Solomidou

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