Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

The New England Journal of Medicine
Roger StuppNational Cancer Institute of Canada Clinical Trials Group

Abstract

Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety. Patients with newly diagnosed, histologically confirmed glioblastoma were randomly assigned to receive radiotherapy alone (fractionated focal irradiation in daily fractions of 2 Gy given 5 days per week for 6 weeks, for a total of 60 Gy) or radiotherapy plus continuous daily temozolomide (75 mg per square meter of body-surface area per day, 7 days per week from the first to the last day of radiotherapy), followed by six cycles of adjuvant temozolomide (150 to 200 mg per square meter for 5 days during each 28-day cycle). The primary end point was overall survival. A total of 573 patients from 85 centers underwent randomization. The median age was 56 years, and 84 percent of patients had undergone debulking surgery. At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12.1 months with ...Continue Reading

References

Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R MacDonaldJ Gregory Cairncross
Jan 1, 1997·Anti-cancer Drugs·S R WedgeE Newlands
Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry S FriedmanP L Modrich
May 11, 2000·The New England Journal of Medicine·J A Kovacs, H Masur
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·J van RijnBen J Slotman
Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Jan 11, 2001·The New England Journal of Medicine·Lisa M DeAngelis
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Medical Research Council Brain Tumor Working Party
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppSerge Leyvraz
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James O ArmitageStewart Kroll
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Monika HegiRoger Stupp
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandrine OstermannRoger Stupp
Jul 15, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fatma AtamanRené-Olivier Mirimanoff
Mar 11, 2005·The New England Journal of Medicine·Monika HegiRoger Stupp

Citations

Nov 10, 2010·Archives of Neurology·Juan FueyoW K Alfred Yung
Jul 3, 2013·EMBO Molecular Medicine·Florian A SiebzehnrublDennis A Steindler
Dec 14, 2006·Current Oncology Reports·Terri Armstrong, Mark R Gilbert
Dec 14, 2006·Current Oncology Reports·H Ian RobinsMinesh Mehta
Dec 14, 2006·Current Oncology Reports·Arnab ChakravartiJay S Loeffler
Dec 12, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Sameer AgnihotriGelareh Zadeh
Aug 5, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Reinhard HeydNikolaos Zamboglou
Feb 26, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Guido HenkeClaus Belka
Nov 10, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Georgios IliadisGeorge Fountzilas
Oct 12, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mario BalducciNuma Cellini
Aug 31, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jindrich KopeckýZuzana Macingova
Nov 1, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Johanna GersteinChristian Weiss
Jan 16, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Clark C ChenAlan D'Andrea
Sep 29, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sara G M PiccirilloKhalid Shah
Jun 10, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Guang YangShiguang Zhao
Feb 7, 2008·Der Nervenarzt·Michael Weller
Jul 17, 2010·Der Nervenarzt·Wolfgang Wick, Michael Weller
Jul 30, 2010·Der Nervenarzt·M Bendszus, Michael Platten
Jun 19, 2013·Der Nervenarzt·Michael PlattenW Wick
Aug 21, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Wenwu XiaoKit S Lam
Aug 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·N GalldiksL W Kracht
Feb 17, 2010·European Journal of Nuclear Medicine and Molecular Imaging·D CordierAdrian Merlo
Jan 20, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Javier ArbizuJ A Richter
Mar 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Alexander HeinzelDirk Müller
Oct 12, 2012·European Journal of Nuclear Medicine and Molecular Imaging·N GalldiksKarl-Josef Langen
Apr 29, 2008·Cancer Immunology, Immunotherapy : CII·Michael J CiesielskiRobert A Fenstermaker
Jul 3, 2008·Cancer Immunology, Immunotherapy : CII·Jun WeiAmy B Heimberger
Feb 18, 2009·Cancer Immunology, Immunotherapy : CII·Claire BanissiAntoine F Carpentier
Aug 1, 2012·Cancer Immunology, Immunotherapy : CII·Surasak PhuphanichJohn S Yu
Jun 19, 2013·Cancer Immunology, Immunotherapy : CII·Sara FritzellPeter Siesjö
Jul 27, 2005·Annals of Hematology·Serena De VitaSimona Sica
Mar 3, 2007·Cancer Chemotherapy and Pharmacology·Stewart P JohnsonHenry S Friedman
Apr 9, 2009·Cancer Chemotherapy and Pharmacology·Patrick BeauchesneCharlotte Carnin
Jun 23, 2009·Cancer Chemotherapy and Pharmacology·J Lee VillanoLinda R Bressler
Oct 23, 2009·Cancer Chemotherapy and Pharmacology·Giulio MetroCarmine Maria Carapella
Mar 29, 2011·Cancer Chemotherapy and Pharmacology·Athanassios P Kyritsis, Victor A Levin
May 27, 2011·Cancer Chemotherapy and Pharmacology·J Lee VillanoLinda R Bressler
Aug 19, 2011·Cancer Chemotherapy and Pharmacology·Jana PortnowT W Synold
Sep 29, 2011·Cancer Chemotherapy and Pharmacology·Pei-Ming ChuShih-Hwa Chiou
Mar 10, 2012·Cancer Chemotherapy and Pharmacology·Aaron M TeitelbaumDavid M Ferguson
May 31, 2012·Cancer Chemotherapy and Pharmacology·Rachel GrossmanJaishri Blakeley
Feb 5, 2013·Cancer Chemotherapy and Pharmacology·Howard A Burris
Jan 30, 2013·Cancer Chemotherapy and Pharmacology·Christian GrommesGary E Landreth
Mar 7, 2013·Cancer Chemotherapy and Pharmacology·Luis R Féliz, Apostolia M Tsimberidou
Jan 16, 2007·European Radiology·Stephen J PriceJonathan H Gillard
Mar 28, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Giuseppe BaroneRiccardo Riccardi
Oct 31, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Seok-Gu KangChun Kun Park
Oct 14, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Wei ZhangTao Jiang
Jun 30, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Arti SrivastavaChitra Sarkar
May 12, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tae-Young JungIn-Ah Kim
Aug 21, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kuntal Kanti DasRaj Kumar
Nov 13, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ga-Yeong ShinFrederick F Lang
Jan 16, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Philip J O'HalloranDavid O'Brien
Sep 7, 2007·Acta Neuropathologica·An ClaesPieter Wesseling
Aug 18, 2010·Acta Neuropathologica·Markus J RiemenschneiderGuido Reifenberger
Feb 23, 2008·Journal of Neurology·A SalmaggiAssociazione Italiana di Neuro-oncologia
Feb 26, 2009·Journal of Neurology·Antje WickPeter Hau
May 13, 2009·Journal of Neurology·Melanie S van BreemenC J Vecht
Jan 21, 2011·Journal of Neurology·Júlia MiróJordi Bruna
Oct 4, 2011·Journal of Neurology·Tanja SchlerethFrauke Zipp
Jan 8, 2013·Journal of Neurology·Vasilios KaravasilisGeorge Fountzilas
Nov 22, 2008·Cell and Tissue Research·Elizandra BraganholAna Maria Oliveira Battastini
May 15, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Antonio RozziGaetano Lanzetta
Oct 20, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Robert OlsonMichael McKenzie
Dec 14, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cagdas YavasFadil Akyol
Oct 20, 2011·Amino Acids·Satoru TakeuchiNariyoshi Shinomiya
Mar 29, 2012·Amino Acids·Frank Gaunitz, Alan R Hipkiss
Nov 7, 2008·Brain Tumor Pathology·Takuichiro HideToru Kondo
Jan 12, 2011·Brain Tumor Pathology·Manabu OnishiIsao Date
Jan 29, 2011·Brain Tumor Pathology·Atsushi NatsumeToshihiko Wakabayashi
Nov 4, 2010·Brain Tumor Pathology·Hiroyuki MomotaSoichiro Shibui
Feb 15, 2012·Brain Tumor Pathology·Yoshiko OkitaSoichiro Shibui
Sep 18, 2009·Neurogenetics·Ana Luísa VitalAlberto Orfao
Aug 6, 2009·Molecules and Cells·Deric M Park, Jeremy N Rich
May 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A SalmaggiFrancesca Imbesi
Oct 12, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P GavianiA Salmaggi
Oct 12, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xianzhen ChenQuanbin Zhang
Mar 13, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Paolo FerroliGiovanni Broggi
Feb 9, 2008·Neurosurgical Review·Lee A SelznickJohn H Sampson
Feb 14, 2009·Neurosurgical Review·R Yamanaka
Jun 10, 2011·Neurosurgical Review·Kenichiro IwamiToshihiko Wakabayashi
Aug 26, 2009·International Journal of Clinical Oncology·Tobias Walbert, Mark R Gilbert
Aug 3, 2011·International Journal of Clinical Oncology·Yasunori FujimotoToshiki Yoshimine
Aug 16, 2012·International Journal of Clinical Oncology·Mariangela MassaccesiAlessio Giuseppe Morganti
Jul 11, 2006·Wiener medizinische Wochenschrift·Viktoria FaberChristine Marosi
Sep 1, 2006·Wiener medizinische Wochenschrift·Matthias PreusserJohannes A Hainfellner
Sep 1, 2006·Wiener medizinische Wochenschrift·Annemarie Schratter-Sehn
Sep 1, 2006·Wiener medizinische Wochenschrift·Christine Marosi
Nov 15, 2006·Wiener medizinische Wochenschrift·Christine Marosi
Feb 12, 2011·Wiener medizinische Wochenschrift·Bernhard HolznerJohannes Giesinger
Sep 29, 2009·Biotechnology Letters·Yue-Jun FuAi-Hua Liang
Sep 15, 2010·Cancer Causes & Control : CCC·Lee W JonesDora Il'yasova
Jun 5, 2013·Cell Biology and Toxicology·Panagiotis J VlachostergiosChristos N Papandreou
Feb 16, 2010·Cellular and Molecular Neurobiology·Xing-Gang MaoMing Yan
Nov 18, 2010·Cellular and Molecular Neurobiology·Fabian BeierDagmar Beier
Jun 25, 2013·Cellular and Molecular Neurobiology·Xing-Gang MaoXiang Zhang
Jul 12, 2013·Cellular and Molecular Neurobiology·Zi-shu WangTao Chen
Jul 9, 2013·Clinical & Experimental Metastasis·Bo QiuYunjie Wang
Dec 6, 2012·Digestive Diseases and Sciences·Lafaine M GrantWilliam M Lee
Mar 8, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Richard J ShannonPeter J Hutchinson
Apr 2, 2013·Metabolic Brain Disease·Gerald C WallaceArabinda Das
Oct 20, 2005·Journal of Neuro-oncology·Shaye I MoskowitzRichard A Prayson
Oct 13, 2006·Journal of Neuro-oncology·Antje Ernst-SteckenGerhard Grabenbauer
Apr 10, 2008·Journal of Neuro-oncology·Angelique E SijbenJ Gregory Cairncross
Jul 29, 2008·Journal of Neuro-oncology·Camilo E FadulJ Marc Pipas
Jul 24, 2008·Journal of Neuro-oncology·Christopher A LipinskiJoseph C Loftus
Sep 27, 2008·Journal of Neuro-oncology·E Brannon MorrisAlberto Broniscer
Nov 10, 2009·Journal of Neuro-oncology·Dale DingJohn H Sampson
Jan 12, 2010·Journal of Neuro-oncology·Kurt A JaeckleJan Buckner
Mar 31, 2009·Journal of Neuro-oncology·Nader PouratianJason P Sheehan
May 6, 2009·Journal of Neuro-oncology·Stephanie L PerryJames J Vredenburgh
Jun 30, 2009·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Aug 1, 2009·Journal of Neuro-oncology·Ramon MartinezG Schackert
Aug 12, 2009·Journal of Neuro-oncology·Alfonso BerrocalGENOM Cooperative Group
Nov 11, 2010·Journal of Neuro-oncology·M M Lino, Adrian Merlo
Nov 27, 2010·Journal of Neuro-oncology·Emily S DayJennifer L West
Dec 1, 2010·Journal of Neuro-oncology·Xinmei ZhuHideho Okada
Mar 15, 2011·Journal of Neuro-oncology·Marshall W PitzJaishri Blakeley
May 7, 2011·Journal of Neuro-oncology·Michelle A RudekStuart A Grossman
Jul 12, 2011·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Oct 11, 2011·Journal of Neuro-oncology·Matthew KoshyBridget J McCarthy
Jan 25, 2012·Journal of Neuro-oncology·Fonnet E BleekerS Leenstra
Mar 13, 2012·Journal of Neuro-oncology·Sanath KumarStephen L Brown
Mar 13, 2012·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Jun 13, 2012·Journal of Neuro-oncology·Christopher A BarkerFabio M Iwamoto
Jul 19, 2012·Journal of Neuro-oncology·Kristine DziurzynskiNicholas Levine
Jul 24, 2012·Journal of Neuro-oncology·Andrew S ChiA John Iafrate
Aug 25, 2012·Journal of Neuro-oncology·Phioanh Leia NghiemphuTimothy F Cloughesy
Sep 27, 2012·Journal of Neuro-oncology·Rachel GrossmanJinyuan Zhou
Jan 12, 2013·Journal of Neuro-oncology·Fadila GuessousRoger Abounader
Jan 25, 2013·Journal of Neuro-oncology·Robert J HarrisBenjamin M Ellingson
Jan 24, 2013·Journal of Neuro-oncology·Selby ChenIan Parney
Mar 5, 2013·Journal of Neuro-oncology·Satoshi NakamizoEiji Kohmura
Mar 26, 2013·Journal of Neuro-oncology·Esther A SuswamPeter H King
Mar 26, 2013·Journal of Neuro-oncology·Matthias HoldhoffStuart A Grossman
May 15, 2013·Journal of Neuro-oncology·Graeme F WoodworthPeter C Burger
May 6, 2009·Pharmaceutical Research·Joram SlagerHenry Brem
Apr 14, 2010·Pharmaceutical Research·Rameshwar PatilJulia Y Ljubimova
Dec 1, 2010·Pharmaceutical Research·Nathalie WauthozKarim Amighi
Aug 16, 2008·Pituitary·Rosie BelcherAshley B Grossman
Mar 16, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Margaret F BennewitzErik M Shapiro
Mar 29, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kailiang ZhangChunsheng Kang
Aug 26, 2010·Targeted Oncology·Mustafa Aziz HatibogluAmy B Heimberger
Aug 21, 2010·Targeted Oncology·Markus J RiemenschneiderGuido Reifenberger
Sep 8, 2010·Targeted Oncology·Ghazaleh TabatabaiRoger Stupp
Sep 3, 2010·Targeted Oncology·Silvia Hofer, Andrew B Lassman
Sep 17, 2010·Targeted Oncology·Patrick G Morris, Lauren E Abrey
Feb 23, 2013·Targeted Oncology·Anna J LomaxM Rosenthal
Nov 11, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Haojun ShiXiaoling Lu
Jun 18, 2009·In Vitro Cellular & Developmental Biology. Animal·Anne ClavreulPhilippe Menei
Oct 26, 2005·Current Treatment Options in Oncology·Volker W Stieber, Thomas L Ellis
Oct 13, 2006·Current Treatment Options in Oncology·Lyndon Kim, Michael Glantz
Feb 8, 2008·Current Treatment Options in Oncology·David A ReardonJames J Vredenburgh
Feb 6, 2008·Current Treatment Options in Oncology·Will R VoelzkeGlenn Lesser
Mar 26, 2008·Current Treatment Options in Oncology·Sunit DasKenji Muro
Apr 22, 2009·Current Treatment Options in Oncology·Jimmy Ruiz, Glenn Lesser
May 20, 2011·Current Treatment Options in Oncology·James FinkMarc C Chamberlain
Aug 21, 2012·Current Treatment Options in Oncology·Laura K AguilarE Antonio Chiocca
Mar 5, 2013·Current Treatment Options in Oncology·Stephane DoucetJeffrey J Raizer
Mar 19, 2013·Current Treatment Options in Oncology·Sarah NicholasMichael Lim
Aug 3, 2013·Current Treatment Options in Oncology·Patrick RothMichael Weller
May 4, 2005·Current Neurology and Neuroscience Reports·Santosh KesariPatrick Y Wen
May 4, 2005·Current Neurology and Neuroscience Reports·Roger StuppMonika Hegi
Apr 26, 2006·Current Neurology and Neuroscience Reports·Mark Agulnik, Warren P Mason
Jun 11, 2008·Current Neurology and Neuroscience Reports·Terri Armstrong, Mark R Gilbert
Apr 8, 2009·Current Neurology and Neuroscience Reports·Jennifer L Clarke, Susan M Chang
Apr 8, 2009·Current Neurology and Neuroscience Reports·Elizabeth R GerstnerTracy T Batchelor
May 13, 2010·Current Neurology and Neuroscience Reports·Lakshmi Nayak, Fabio M Iwamoto
Apr 29, 2010·Current Neurology and Neuroscience Reports·Laura A Johnson, John H Sampson
Jan 18, 2012·Current Neurology and Neuroscience Reports·Roger J Packer
Mar 23, 2012·Current Neurology and Neuroscience Reports·Herwig M StrikBart Neyns
Mar 20, 2012·Current Neurology and Neuroscience Reports·Ghazaleh TabatabaiMichael Weller
Mar 27, 2013·Current Neurology and Neuroscience Reports·Olivier ChinotTimothy F Cloughesy
May 15, 2013·Current Neurology and Neuroscience Reports·Linda DirvenMartin J B Taphoorn
Feb 9, 2006·Current Oncology Reports·Mark R Gilbert
Feb 9, 2006·Current Oncology Reports·René-Olivier Mirimanoff
Feb 9, 2006·Current Oncology Reports·Monika Hegi, Roger Stupp
Feb 9, 2006·Current Oncology Reports·Santosh KesariPatrick Y Wen
Mar 29, 2006·Current Oncology Reports·Paul D Brown
Dec 17, 2008·Current Oncology Reports·Douglas E Ney, Andrew B Lassman
Apr 29, 2010·Current Oncology Reports·Mustafa Khasraw, Andrew B Lassman
Apr 29, 2010·Current Oncology Reports·Patrick Y WenEudocia Quant
Dec 14, 2011·Current Oncology Reports·Sean A Grimm
Nov 6, 2012·Current Oncology Reports·Derek R Johnson, Evanthia Galanis
Dec 19, 2012·Current Oncology Reports·Andrew B Lassman
Dec 12, 2012·Current Oncology Reports·Emma B Holliday, Erik P Sulman
Jun 6, 2013·Current Oncology Reports·Sidnei Epelman
Jun 27, 2008·Current Treatment Options in Neurology·Jaishri Blakeley, Stuart A Grossman
Jun 16, 2009·Current Treatment Options in Neurology·Andreas F Hottinger, Yasmin Khakoo
Jun 16, 2009·Current Treatment Options in Neurology·Brian Vaillant, Monica Loghin
Sep 16, 2010·Current Treatment Options in Neurology·Pierre Giglio, J Lee Villano
Apr 13, 2011·Current Treatment Options in Neurology·Alba A Brandes, Enrico Franceschi
Apr 19, 2011·Current Treatment Options in Neurology·Brett J Theeler, Morris D Groves
Feb 19, 2013·Current Treatment Options in Neurology·Jennie Taylor, Elizabeth R Gerstner
Feb 27, 2013·Current Treatment Options in Neurology·Jane E Minturn, Michael J Fisher
Apr 5, 2013·Current Treatment Options in Neurology·Eudocia Q LeeDavid A Reardon
Apr 2, 2013·Current Treatment Options in Neurology·Sean A Grimm, Thomas J Pfiffner
May 15, 2012·Medical Oncology·Alba FiorentinoVincenzo Fusco
Oct 24, 2007·Molecular Neurobiology·Guillermo VelascoManuel Guzmán
Oct 16, 2012·Molecular Neurobiology·Sylvain FerrandonDelphine Poncet
Apr 30, 2013·Molecular Neurobiology·Amanda Tivnan, Kerrie McDonald
Nov 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ana Paula CaresiaXavier Maldonado
Nov 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jorge Contreras MartínezIsmael Herruzo Cabrera
Jun 23, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carmen Balaña Quintero, GENOM
Dec 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carmen BalañaRafael Rosell
May 21, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Pérez CastilloJ Dorado
May 14, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A CustodioPedro Peréz-Segura
Mar 23, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carmen BalañaAlex Martínez
Apr 16, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Leoncio Arribas AlpuenteRicardo Yayá Tur
Aug 26, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carmen BalańaRafael Rosell
Oct 7, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Eugènia VergerFrancesc Graus
Jun 23, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Alfonso BerrocalSEOM (Spanish Society of Clinical Oncology)
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Izaskun ValduviecoFrancesc Graus
Sep 18, 2010·Pathology Oncology Research : POR·Biao ZhangHongsheng Liu
Dec 20, 2012·Pathology Oncology Research : POR·Despina TelevantouVassiliki Kotoula
Jul 5, 2013·Pathology Oncology Research : POR·Zhifan JiaPeiyu Pu
Jan 26, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yugo KishidaToshihiko Wakabayashi
Jan 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ibrahim ErkutluCelalettin Camci
Apr 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andrej BesseOndrej Slaby
Dec 15, 2012·CNS Drugs·Rupert BartschMatthias Preusser
Jan 19, 2013·Paediatric Drugs·Trent R HummelDavid Franz
May 31, 2013·Paediatric Drugs·Rejin Kebudi, Fatma Betul Cakir
Sep 26, 2013·Advanced Drug Delivery Reviews·Yu ChengMaciej S Lesniak
Feb 5, 2014·Advanced Drug Delivery Reviews·Swapnil V BhujbalSimone P Niclou
Jan 1, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Anja SanderDetlef Gabel
Dec 21, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Raymond L Moss
Feb 1, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Teruyoshi KagejiH Kumada
Jan 21, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Toshiyuki OkazakiShinji Nagahiro
Jan 28, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·N MirzajaniF d'Errico
Jul 31, 2013·Biochimica Et Biophysica Acta·Anne Vehlow, Nils Cordes
Jun 26, 2013·Biochemical and Biophysical Research Communications·Ju Mei LiuXiao Qian Chen
Apr 26, 2012·Cancer Letters·S KrethF W Kreth
Dec 4, 2012·Cancer Letters·Delphine Tamara Marie-EgyptienneRichard Peter Hill
Sep 10, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·V MartinA Laprie
May 28, 2013·Clinical Neurology and Neurosurgery·Orin BlochAndrew T Parsa
Jul 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ranjith BabuCory Adamson
Aug 10, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kaisorn L ChaichanaAlfredo Quiñones-Hinojosa
Jun 19, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Y SiaKatharine J Drummond
Sep 26, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jonathan P MannasJ Lee Villano
Oct 22, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jonathan H ShermanIsa M Hussaini
Jan 15, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sharon Yin Yee LowWai Hoe Ng
Dec 18, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Omprakash DamodaranGabriel Lee
Jan 2, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mario AmmiratiJohn Grecula
Apr 22, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Simon V LiubinasAndrew H Kaye
Oct 22, 2013·Revue neurologique·D GokcekA Idbaih
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Duane A Mitchell, John H Sampson
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew S ChiPatrick Y Wen
Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Susan NoellRainer Ritz
Jul 28, 2013·World Neurosurgery·Asita S SarrafzadehAndreas Unterberg
Feb 11, 2014·World Neurosurgery·Kaisorn L ChaichanaAlfredo Quiñones-Hinojosa
Dec 18, 2010·Lancet Neurology·Motoo Nagane
Jun 17, 2011·Expert Reviews in Molecular Medicine·Sagar AgarwalWilliam F Elmquist
May 29, 2010·Analytical Chemistry·Yinni YuAlexander Chagovetz
Feb 18, 2012·Journal of Medicinal Chemistry·Michael W RobinsonWilliam A Maltese
Jan 25, 2012·Journal of Medicinal Chemistry·Ludovic ClarionNorbert Bakalara
Jun 13, 2009·Cell Death and Differentiation·Jakub GodlewskiS E Lawler
Dec 4, 2010·Cell Death and Differentiation·A B HjelmelandJeremy N Rich
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sandrine RoriveIsabelle Salmon
Jan 15, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicole SimonaviciusClare M Isacke
Aug 30, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Costas George HadjipanayisNeal A Deluca
Oct 30, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·James M MarkertGeorge Y Gillespie
Oct 22, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jayson HardcastleBalveen Kaur
Nov 12, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Darnell T JosiahHannah Caldas
Jul 8, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuzo HasegawaYoshikazu Yonemitsu
Apr 22, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel BexellJohan Bengzon
Oct 28, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ji Young YooBalveen Kaur
Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gwendalyn D KingPedro R Lowenstein
Aug 30, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kaoru TamuraKhalid Shah
Oct 17, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kevin K H ChowStephen Gottschalk
Feb 23, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Eleonora GambiniPaolo Malatesta
Apr 12, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Raphael BergesJoel Eyer
May 2, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Omar D PerezDouglas J Jolly
Jul 26, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chung Kwon KimMaciej S Lesniak
Aug 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Meenakshi HegdeNabil Ahmed
Nov 10, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kendra L Congdon, John H Sampson
May 8, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·M Sarah S BovenbergBakhos A Tannous
Feb 9, 2007·Nature Biotechnology·Roger Stupp, Monika Hegi
Aug 26, 2006·Nature Clinical Practice. Neurology·Warren P Mason, J Gregory Cairncross
Aug 26, 2006·Nature Clinical Practice. Neurology·Paul S Mischel, Timothy F Cloughesy
Nov 30, 2007·Nature Clinical Practice. Neurology·Robert C Castellino, Donald L Durden
Jul 17, 2008·Nature Clinical Practice. Neurology·Sunit DasJohn A Kessler
Feb 8, 2006·Nature Clinical Practice. Oncology·David A Reardon
Jun 8, 2006·Nature Clinical Practice. Oncology·Vincent GanièreRoger Stupp
Mar 1, 2007·Nature Clinical Practice. Oncology·Soren M BentzenJacques Bernier
Jun 11, 2008·Nature Clinical Practice. Oncology·Maciej M Mrugala, Marc C Chamberlain
Aug 7, 2013·Nature Genetics·Veronique FrattiniAntonio Iavarone
Sep 24, 2013·Nature Medicine·Stephanie M PyonteckJohanna A Joyce
Oct 9, 2013·Nature Medicine·Christopher Garris, Mikael J Pittet
Sep 27, 2013·Nature Neuroscience·Shirin Ilkhanizadeh, William A Weiss
May 26, 2006·Nature Reviews. Cancer·Angelo L VescoviBrent A Reynolds
Feb 8, 2008·Nature Reviews. Cancer·Thomas HelledayRicky A Sharma
Apr 24, 2010·Nature Reviews. Cancer·Jason T Huse, Eric C Holland
May 5, 2012·Nature Reviews. Cancer·Guillermo VelascoManuel Guzmán
Oct 7, 2009·Nature Reviews. Clinical Oncology·Isaac Yang, Manish K Aghi
Feb 2, 2010·Nature Reviews. Clinical Oncology·Deric M ParkJeremy N Rich
Jun 24, 2009·Nature Reviews. Clinical Oncology·A WaldmanNational Cancer Research Institute Brain Tumour Imaging Subgroup
Jun 10, 2010·Nature Reviews. Clinical Oncology·Eddy PasquierNicolas André
Nov 28, 2012·Nature Reviews. Clinical Oncology·Shota TanakaJorg Dietrich
May 30, 2012·Nature Reviews. Clinical Oncology·Chris JonesDarren Hargrave
Oct 15, 2009·Nature Reviews. Neurology·Andrew D NordenPatrick Y Wen
Dec 10, 2009·Nature Reviews. Neurology·Michael WellerMonika Hegi
Jul 15, 2009·Nature Reviews. Neurology·Benjamin Purow, David Schiff
Nov 14, 2012·Nature Reviews. Neurology·Alba A Brandes, Marco Bartolotti
Apr 25, 2012·Nature Reviews. Neurology·Maya Srikanth, John A Kessler
Apr 3, 2013·Oncogenesis·Tim ForshewP J Mulholland
Mar 21, 2012·Pediatric Research·Pedro Castelo-Branco, Uri Tabori
Feb 4, 2006·Cell Death and Differentiation·Adriana EramoR De Maria
Sep 20, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Johan SkogGöran Wadell
Feb 20, 2013·Biologie aujourd'hui·Jean-Pierre Benoit
Jun 3, 2005·The New England Journal of Medicine·Arnold C Paulino, Bin S Teh
Apr 13, 2007·The New England Journal of Medicine·Jai GrewalW K Alfred Yung
Jul 13, 2007·The New England Journal of Medicine·Stephen Hanna
May 22, 2009·The New England Journal of Medicine·Emilie De CarliStéphanie Puget
Mar 11, 2005·The New England Journal of Medicine·Lisa M DeAngelis
Mar 11, 2005·The New England Journal of Medicine·Monika HegiRoger Stupp
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Dec 24, 2010·The New England Journal of Medicine·Markus BredelGriffith Harsh
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Jul 6, 2012·The New England Journal of Medicine·Allan H Ropper
Jun 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryo UedaHideho Okada
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·W Ruprecht WiedemeyerLynda Chin
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adília HormigoShahin Rafii
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eun Sung ParkJu-Seog Lee
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Silvia TerésPablo V Escribá
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Shrirang KarveAndrew Z Wang
Feb 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrea SottorivaSimon Tavaré
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tracy T BatchelorRakesh K Jain
Sep 28, 2010·The Journal of Biological Chemistry·Claudia R OlivaCorinne E Griguer
Oct 12, 2011·The Journal of Biological Chemistry·Hiroaki IkushimaKohei Miyazono
Jul 11, 2012·The Journal of Biological Chemistry·Irina V BalyasnikovaMaciej S Lesniak
Sep 12, 2012·Molecular & Cellular Proteomics : MCP·Hannah JohnsonForest M White
Jul 1, 2010·AJOB Neuroscience·Lisa Anderson-ShawJ Lee Villano
Jun 19, 2013·The Journal of Cell Biology·Grzegorz NalepaWade Clapp
Jan 19, 2011·The Journal of Experimental Medicine·Amparo WolfAbhijit Guha
Apr 6, 2011·The Journal of Experimental Medicine·Sameer AgnihotriAbhijit Guha
Dec 14, 2011·The Journal of Experimental Medicine·Ming LiFrank Furnari
Feb 27, 2008·Cancer Biotherapy & Radiopharmaceuticals·Frits AartsOtto C Boerman
Dec 2, 2010·Genetic Testing and Molecular Biomarkers·Gang BaoGaofeng Xu
Apr 17, 2013·Omics : a Journal of Integrative Biology·Edmond Changkyun ParkGun-Hwa Kim
Jan 27, 2011·Stem Cells and Development·Paul RammChristoph P Beier
Aug 15, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J SigmondG J Peters
Aug 9, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M SchaichD Krex
Jul 10, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Roger StuppESMO Guidelines Working Group
Jan 13, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Joost J C VerhoeffD J Richel
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Roger StuppESMO Guidelines Working Group
Aug 18, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ChargariE Deutsch
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Andreas F HottingerRoger Stupp
Jan 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SonpavdeG Di Lorenzo
Oct 17, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F-W KrethGerman Glioma Network
Feb 5, 2013·Brain : a Journal of Neurology·Patrick RothMichael Weller
Dec 4, 2012·Human Molecular Genetics·Pedro M CostaMaria C Pedroso de Lima
Oct 11, 2008·Japanese Journal of Clinical Oncology·Toshihiko WakabayashiJun Yoshida
Apr 7, 2010·Japanese Journal of Clinical Oncology·Yasuyoshi ChibaToshiki Yoshimine
Mar 9, 2012·Japanese Journal of Clinical Oncology·Shigeru YamaguchiKiyohiro Houkin
Apr 25, 2012·Japanese Journal of Clinical Oncology·Hiroki HayashiAkihiko Gemma
Jul 31, 2012·Japanese Journal of Clinical Oncology·Motoo NaganeMasao Matsutani
Apr 16, 2013·Japanese Journal of Clinical Oncology·Yoshitaka Narita
Jan 5, 2006·Journal of the National Cancer Institute·Manish K AghiRobert L Martuza
Apr 19, 2007·Journal of the National Cancer Institute·Teri-T B NgoJohn K Park
Dec 18, 2010·Journal of the National Cancer Institute·Brock C ChristensenJohn Wiencke
Jul 21, 2011·Journal of the National Cancer Institute·Lincoln A EdwardsHoward A Fine
Dec 17, 2011·Journal of the National Cancer Institute·Ryuichi KanaiRobert L Martuza
Dec 13, 2012·Journal of the National Cancer Institute·Yaacov Richard LawrenceAdam P Dicker
Aug 14, 2013·Journal of the National Cancer Institute·Bakhos A TannousThomas Würdinger
Oct 19, 2013·Journal of the National Cancer Institute·Mei-Yin C PolleyLisa M McShane
Feb 13, 2010·Neuro-oncology·Howard ColmanKen Aldape
Feb 13, 2010·Neuro-oncology·Marie-Thérése StockhausenHans Skovgaard Poulsen
Feb 13, 2010·Neuro-oncology·Teri Nguyen KreislHoward A Fine
Jun 1, 2010·Neuro-oncology·Eefje M SizooMartin J B Taphoorn
Feb 20, 2010·Neuro-oncology·Michael Weller
Apr 7, 2010·Neuro-oncology·Luc BauchetAssociation des Neuro-Oncologues d'Expression Française (ANOCEF)
Apr 15, 2010·Neuro-oncology·Michael D BloughJ Gregory Cairncross
May 18, 2010·Neuro-oncology·David AkhavanPaul S Mischel
Jul 16, 2010·Neuro-oncology·Michael RasperJürgen Schlegel
Jul 10, 2010·Neuro-oncology·W K Alfred YungMichael D Prados
Dec 15, 2010·Neuro-oncology·Amy B Heimberger, John H Sampson
Feb 12, 2011·Neuro-oncology·David A ReardonPatrick Y Wen
Jun 4, 2011·Neuro-oncology·Wolfgang WickMichael Platten
Jun 4, 2011·Neuro-oncology·Andrew B LassmanKatherine Panageas
Jul 16, 2011·Neuro-oncology·Christian la FougèreJörg-Christian Tonn
Aug 13, 2011·Neuro-oncology·Fabio M IwamotoAdília Hormigo
Sep 13, 2011·Neuro-oncology·Derek A WainwrightMaciej S Lesniak
Nov 10, 2011·Neuro-oncology·Hiroaki WakimotoSamuel D Rabkin
Feb 7, 2012·Neuro-oncology·Elizabeth FordLesley Fallowfield
Jun 5, 2012·Neuro-oncology·Katherine PanageasAndrew B Lassman