Radiotherapy timing in 4,820 patients with breast cancer: university of florence experience

International Journal of Radiation Oncology, Biology, Physics
Lorenzo LiviGiampaolo Biti

Abstract

To analyze the relationship between a delay in radiotherapy (RT) after breast-conserving surgery and ipsilateral breast recurrence (BR). We included in our analysis 4,820 breast cancer patients who had undergone postoperative RT at the University of Florence. The patients were categorized into four groups according to the interval between surgery and RT (T1, <60 days; T2, 61-120 days; T3, 121-180 days; and T4, >180 days). On multivariate analysis, the timing of RT did not reach statistical significance in patients who received only postoperative RT (n = 1,935) or RT and hormonal therapy (HT) (n = 1,684) or RT, chemotherapy (CHT), and HT (n = 529). In the postoperative RT-only group, age at presentation, surgical margin status, and a boost to the tumor bed were independent prognostic factors for BR. In the RT plus HT group, age at presentation and boost emerged as independent prognostic factors for BR (p = 0.006 and p = 0.049, respectively). Finally, in the RT, CHT, and HT group, only multifocality was an independent BR predictor (p = 0.01). Only in the group of patients treated with RT and CHT (n = 672) did multivariate analysis with stepwise selection show RT timing as an independent prognostic factor (hazard ratio, 1.59; 95% ...Continue Reading

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Citations

May 24, 2012·Journal of Drug Delivery·Jun H Lee, Anjan Nan
Nov 3, 2010·The Oncologist·Pelagia G TsoutsouUNKNOWN Association of Radiotherapy and Oncology in the Mediterranean area (AROME)
Mar 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S CorradiniS Kahlert
Aug 24, 2010·International Journal of Radiation Oncology, Biology, Physics·Per KarlssonUNKNOWN International Breast Cancer Study Group
May 24, 2016·The Breast : Official Journal of the European Society of Mastology·C RenaudeauJ M Classe

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