Abstract
To analyze the relationship between a delay in radiotherapy (RT) after breast-conserving surgery and ipsilateral breast recurrence (BR). We included in our analysis 4,820 breast cancer patients who had undergone postoperative RT at the University of Florence. The patients were categorized into four groups according to the interval between surgery and RT (T1, <60 days; T2, 61-120 days; T3, 121-180 days; and T4, >180 days). On multivariate analysis, the timing of RT did not reach statistical significance in patients who received only postoperative RT (n = 1,935) or RT and hormonal therapy (HT) (n = 1,684) or RT, chemotherapy (CHT), and HT (n = 529). In the postoperative RT-only group, age at presentation, surgical margin status, and a boost to the tumor bed were independent prognostic factors for BR. In the RT plus HT group, age at presentation and boost emerged as independent prognostic factors for BR (p = 0.006 and p = 0.049, respectively). Finally, in the RT, CHT, and HT group, only multifocality was an independent BR predictor (p = 0.01). Only in the group of patients treated with RT and CHT (n = 672) did multivariate analysis with stepwise selection show RT timing as an independent prognostic factor (hazard ratio, 1.59; 95% ...Continue Reading
References
Sep 1, 1986·International Journal of Radiation Oncology, Biology, Physics·G H Fletcher
May 1, 1985·Cancer·H R Withers
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·A J NixonJ R Harris
Jun 3, 1993·The New England Journal of Medicine·U VeronesiT Savio
Sep 14, 1996·Lancet·A P ForrestW D George
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·O VujovicP T Truong
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·P J FroudI A Olivotto
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·W J MackillopH R Withers
Jun 11, 2005·Cancer·Mohamed BenchalalPierre Kerbrat
Apr 6, 2006·Breast Cancer Research and Treatment·Jan J JobsenJacobus H Meerwaldt
Sep 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Olga VujovicFrancisco Perera
Dec 26, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lorenzo LiviGiampaolo P Biti
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry BartelinkLaurence Collette
Nov 7, 2007·The Breast Journal·Giampiero Ausili CèfaroMarta Di Nicola
Citations
Mar 4, 2010·BMJ : British Medical Journal·Rinaa S PungliaJane C Weeks
May 24, 2012·Journal of Drug Delivery·Jun H Lee, Anjan Nan
Nov 3, 2010·The Oncologist·Pelagia G TsoutsouUNKNOWN Association of Radiotherapy and Oncology in the Mediterranean area (AROME)
Feb 19, 2014·Medical Oncology·Icro MeattiniLorenzo Livi
Mar 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S CorradiniS Kahlert
Aug 24, 2010·International Journal of Radiation Oncology, Biology, Physics·Per KarlssonUNKNOWN International Breast Cancer Study Group
Apr 4, 2015·World Neurosurgery·Dhruv M PatelIra M Goldstein
May 24, 2016·The Breast : Official Journal of the European Society of Mastology·C RenaudeauJ M Classe
Aug 9, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·S GuptaW J Mackillop
Apr 18, 2013·Journal of breast cancer·Taehyun Kim, Heunglae Cho
Aug 16, 2016·European Journal of Medical Research·Raffaella CaponioMarco Lioce
Oct 12, 2017·Medicine·Ying LuDagui Chen
Jun 8, 2017·British Journal of Cancer·Marissa C van MaarenSabine Siesling
Jun 6, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hyeon Kang KohSung Whan Ha
Oct 20, 2020·Frontiers in Oncology·Si-Ye ChenYe-Xiong Li