Radiotherapy volume delineation based on ((18)F)-fluorodeoxyglucose positron emission tomography for locally advanced or inoperable oesophageal cancer

Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
J EncaouaU Schick

Abstract

To study the impact on radiotherapy planning of an automatically segmented target volume delineation based on ((18)F)-fluorodeoxy-D-glucose (FDG)-hybrid positron emission tomography-computed tomography (PET-CT) compared to a manually delineation based on computed tomography (CT) in oesophageal carcinoma patients. Fifty-eight patients diagnosed with oesophageal cancer between September 2009 and November 2014 were included. The majority had squamous cell carcinoma (84.5 %), and advanced stage (37.9 % were stade IIIA) and 44.8 % had middle oesophageal lesion. Gross tumour volumes were retrospectively defined based either manually on CT or automatically on coregistered PET/CT images using three different threshold methods: standard-uptake value (SUV) of 2.5, 40 % of maximum intensity and signal-to-background ratio. Target volumes were compared in length, volume and using the index of conformality. Radiotherapy plans to the dose of 50Gy and 66Gy using intensity-modulated radiotherapy were generated and compared for both data sets. Planification target volume coverage and doses delivered to organs at risk (heart, lung and spinal cord) were compared. The gross tumour volume based manually on CT was significantly longer than that autom...Continue Reading

Citations

Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Philippe BulensKarin Haustermans
Aug 24, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S ThureauP Vera
Apr 15, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·V IsnardiP Vera

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