Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds

Circulation. Cardiovascular Imaging
Jessica L AlveloMitchel R Stacy

Abstract

Single photon emission computed tomography (SPECT)/computed tomography (CT) imaging allows for assessment of skeletal muscle microvascular perfusion but has not been quantitatively assessed in angiosomes, or 3-dimensional vascular territories, of the foot. This study assessed and compared resting angiosome foot perfusion between healthy subjects and diabetic patients with critical limb ischemia (CLI). Additionally, the relationship between SPECT/CT imaging and the ankle-brachial index-a standard tool for evaluating peripheral artery disease-was assessed. Healthy subjects (n=9) and diabetic patients with CLI and nonhealing ulcers (n=42) underwent SPECT/CT perfusion imaging of the feet. CT images were segmented into angiosomes for quantification of relative radiotracer uptake, expressed as standardized uptake values. Standardized uptake values were assessed in ulcerated angiosomes of patients with CLI and compared with whole-foot standardized uptake values in healthy subjects. Serial SPECT/CT imaging was performed to assess uptake kinetics of technetium-99m-tetrofosmin. The relationship between angiosome perfusion and ankle-brachial index was assessed via correlational analysis. Resting perfusion was significantly lower in CLI ve...Continue Reading

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Citations

Feb 28, 2019·Vascular and Endovascular Surgery·Leila HaghighatCarlos I Mena-Hurtado
Sep 5, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ting-Heng Chou, Mitchel R Stacy
Dec 5, 2019·International Journal of Molecular Sciences·Camilo A Ruiz-BedoyaSanjay K Jain
May 12, 2018·Circulation. Cardiovascular Imaging·J Paul Finn, Peter F Lawrence
Jul 28, 2021·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Jie ZhengMary K Hastings

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Methods Mentioned

BETA
amputation
amputations
imaging techniques
X-ray

Software Mentioned

GraphPad
SAS
GraphPad Prism
BioImage Suite
STAT
Xeleris

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