Abstract
Purpose: This study investigates the biologic activity of radium-223 with VEGF-targeted therapy in patients with advanced renal cell carcinoma (aRCC) and bone metastases.Patients and Methods: Fifteen treatment-naïve patients (n = 15) received pazopanib 800 mg orally once daily, and 15 previously treated patients received sorafenib 400 mg orally twice daily. Radium-223 55 kilobecquerel/kg was administered concurrently every 4 weeks for up to six infusions in both cohorts. The primary endpoint was decline in bone turnover markers (Procollagen I Intact N-Terminal, N-telopeptide, C-telopeptide, osteocalcin, and bone-specific alkaline phosphatase) compared with baseline. Secondary endpoints included safety, rate of symptomatic skeletal event (SSE) and time to first SSE, objective response rate, change in analgesic use, and quality of life. Exploratory analysis of tumor genomic alterations was performed.Results: Of the 30 patients enrolled, 83% had IMDC intermediate- or poor-risk disease, 33% had liver metastases, and 83% had a history of SSE prior to enrollment. No dose-limiting toxicity was observed. All bone turnover markers significantly declined from baseline at week 8 and 16. Forty percent of patients experienced treatment-rela...Continue Reading
References
Oct 1, 1983·Pain·R L DautR C Flanery
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tsuyoshi HamaokaNaoto T Ueno
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert E Coleman
Jun 5, 2007·The Lancet Oncology·Sten NilssonOyvind S Bruland
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierRonald M Bukowski
Apr 10, 2009·Journal of Pain and Symptom Management·Deepa RaoDavid Cella
May 27, 2010·The Journal of Biological Chemistry·Liza J Raggatt, Nicola C Partridge
Sep 22, 2010·Bone·Emma WoodwardJanet Brown
Sep 6, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BianchiP I Karakiewicz
Nov 8, 2011·Lancet·Brian I RiniRobert J Motzer
Jul 11, 2012·Cancer·Zeeshan ButtDavid Cella
Jun 27, 2013·British Journal of Cancer·A AlcarazUNKNOWN TUGAMO GROUP
Jul 19, 2013·The New England Journal of Medicine·C ParkerUNKNOWN ALSYMPCA Investigators
Aug 22, 2013·European Urology·Rana R McKayToni K Choueiri
Aug 24, 2013·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Dec 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Helen YuEl Bachir Affar
Jan 5, 2014·The Journal of Urology·Carina AntczakQuoc-Dien Trinh
Jan 5, 2014·PloS One·Daniele SantiniSergio Bracarda
Jan 10, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Karen C ChungMartin Zagari
Mar 13, 2014·European Urology·Rana R McKayToni K Choueiri
Apr 15, 2014·Breast Cancer Research and Treatment·Robert ColemanPatrick Flamen
May 14, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James Brugarolas
Dec 20, 2015·Journal of the National Cancer Institute·Diane S AbouDaniel L J Thorek
Jun 25, 2016·International Journal of Molecular Sciences·Szu-Chia Chen, Po-Lin Kuo
Nov 25, 2016·JCI Insight·Lynette M ShollLaura E MacConaill
Jan 26, 2017·The New England Journal of Medicine·Toni K Choueiri, Robert J Motzer
Apr 2, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mari I SuominenArne Scholz
Jan 9, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierToni K Choueiri
Citations
Sep 1, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Sabina DizdarevicSobhan Vinjamuri
Mar 13, 2020·Drug Development and Industrial Pharmacy·Ming JingXue-Tao Li
Jan 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neeraj AgarwalBenjamin L Maughan
Apr 2, 2021·ChemMedChem·Natalia Herrero ÁlvarezJason S Lewis
Jan 12, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lilja B SolnesSteven P Rowe
Jul 3, 2021·Pharmaceutics·Romain EychenneJean-François Gestin
Nov 2, 2021·Current Medical Research and Opinion·Wenhao SuWenjie Jiao