Radix Astragali and Radix Rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues

Phytotherapy Research : PTR
T W LauY Y Ho

Abstract

Over 194 million people suffer from diabetes worldwide. The improper control of diabetes may result in diabetic foot ulcer or even amputation. Herbal medicine provides a means for treating diabetic foot ulcers for a large population in developing countries. The wound healing-enhancing activities of the principal herbs, Radix Astragali (RA) and Radix Rehmanniae (RR) in two clinically efficacious Chinese herbal formulae were studied in primary fibroblasts from diabetic foot ulcer patients. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that RA and RR significantly enhanced the viability of fibroblasts isolated from foot ulcers of diabetic patients, even from those with no response to insulin treatment. The results in this study indicate that fibroblast viability enhancement effects of RA and RR likely underlie the healing effects of F1 and F2 in diabetic foot ulcers.

References

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Citations

Aug 3, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Min ChenChun-Guang Xie
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Li-Hua PengJian-Qing Gao
Dec 7, 2011·Journal of Ethnopharmacology·Xi ChenJian-Qing Gao
Feb 5, 2011·Journal of Ethnopharmacology·Jacqueline Chor Wing TamClara Bik San Lau
Oct 28, 2015·The Cochrane Database of Systematic Reviews·Jian LiuKeHu Yang
May 29, 2018·Mediators of Inflammation·Tarcisio Vitor Augusto LordaniMaria Valdrinez Campana Lonardoni
May 11, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Morteza Najaf Zadeh GharaboghazShahram Saghaie

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