Radon as a Tracer of Lung Changes Induced by Smoking

Risk Analysis : an Official Publication of the Society for Risk Analysis
R BöhmK Holý

Abstract

After smoking, exposure to radon and its progeny is the second leading cause of lung cancer. The probability of inducing lung carcinomas by inhaled radon progeny depends on the deposited radiation dose, and is significantly affected by physiological and morphometric changes induced by smoking. Due to irritation of the airways, the inhalation of cigarette smoke leads to the hyperproduction of mucus. Two concurrent processes occur: on one hand, increased production of mucus protects the target cells against radiation damage; on the other hand, in the case of long-term smokers, a chronic lung obstruction develops, causing an increase in the radiation dose to the lungs. Depending on the duration and intensity of smoking, these processes contribute to the final radiation dose with different weights. The primary objective of this study was to investigate to what extent these smoke-induced changes can modify the resulting absorbed dose of inhaled radon progeny relative to healthy nonsmokers. Since the bronchial dose depends on the degree of lung tissue damage, we have used this dose as a tool for detecting the effects of smoking on the lung epithelium. In other words, the biological effect of radon served as a tracer of changes induce...Continue Reading

References

May 31, 2001·International Journal of Radiation Biology·D Nikezic, K N Yu
Oct 29, 2003·Radiation Protection Dosimetry·D KrewskiS H Moolgavkar
Jan 24, 2006·Journal of Hazardous Materials·K N YuD Nikezic
Sep 22, 2009·Radiation Protection Dosimetry·Paul F BaiasOctavian G Duliu
Dec 4, 2019·Radiation Protection Dosimetry·R BöhmK Holý

Related Concepts

Inspiration Function
Lung
Chronic Obstructive Airway Disease
Mucous Body Substance
Radon
Bronchial
Cigarette smoke (substance)
Malignant Neoplasm of Lung
Radiation Damage to Artery
Airway Structure

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