Radon exposure and oropharyngeal cancer risk

Cancer Letters
Tania Salgado-EspinosaAlberto Ruano-Ravina

Abstract

Oropharyngeal cancer is a multifactorial disease. Alcohol and tobacco are the main risk factors. Radon is a human carcinogen linked to lung cancer risk, but its influence in other cancers is not well known. We aim to assess the effect of radon exposure on the risk of oral and pharyngeal cancer through a systematic review of the scientific literature. This review performs a qualitative analysis of the available studies. 13 cohort studies were included, most of them mortality studies, which analysed the relationship between occupational or residential radon exposure with oropharyngeal cancer mortality or incidence. Most of the included studies found no association between radon exposure and oral and pharyngeal cancer. This lack of effect was observed in miners studies and in general population studies. Further research is necessary to quantify if this association really exists and its magnitude, specially performing studies in general population, preferably living in areas with high radon levels.

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Citations

Jun 9, 2016·Gaceta sanitaria·José Antonio García-LavandeiraJuan Miguel Barros-Dios
Jun 9, 2016·Journal of Toxicology and Environmental Health. Part a·Xing LiuJian Tong
Jul 19, 2019·Expert Review of Respiratory Medicine·María Lorenzo-GonzálezAlberto Ruano-Ravina
Jun 30, 2019·Yonsei Medical Journal·Jin Kyu KangYoung Woo Jin
Oct 18, 2020·International Journal of Environmental Research and Public Health·Silvia Gómez-Anca, Juan Miguel Barros-Dios
Nov 5, 2019·Gaceta sanitaria·Eduardo Alarcón-CapelJuan M Barros-Dios
Dec 18, 2020·Toxics·Anna Grzywa-CelińskaKrzysztof Kozak

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