Rafts, little caves and large potholes: how lipid structure interacts with membrane proteins to create functionally diverse membrane environments

Sub-cellular Biochemistry
Roger J MorrisPeter J Quinn

Abstract

This chapter reviews how diverse lipid microdomains form in the membrane and partition proteins into different functional units that regulate cell trafficking, signalling and movement. We will concentrate upon five major issues: 1. the diversity of lipid structure that produces diverse microenvironments into which different subsets of proteins partition; 2. why ordered lipid domains exclude proteins, and the conditions required for select subsets of proteins to enter these domains; 3. the coupling of the inner and outer leaflets within ordered microdomains; 4. the effect of ordered lipid domains upon membrane properties including curvature and hydrophobicity that affect membrane fission, fusion and extension of filopodia; 5. the biological effects of these structural constraints; in particular how the properties of these domains combine to provide a very different signalling, trafficking and membrane fusion environment to that found in disordered (fluid mosaic) membrane. In addressing these problems, the review draws upon studies ranging from molecular dynamic modelling of lipid interactions, through physical studies of model membrane systems to structural and biological studies of whole cells, examining in the process problems...Continue Reading

Citations

Aug 21, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Feng XuePatrick J Prendergast
Mar 20, 2004·Traffic·Philippe F Devaux, Roger Morris
Jun 10, 2008·Lipids·Avery L McIntoshFriedhelm Schroeder
Jan 9, 2019·Frontiers in Cell and Developmental Biology·Roger J Morris
Apr 27, 2007·PloS One·Komla SoboF Gisou van der Goot
Jan 4, 2006·Biochimica Et Biophysica Acta·Gordan Lauc, Marija Heffer-Lauc
Dec 28, 2007·Free Radical Biology & Medicine·Jeffrey AtkinsonRichard M Epand

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