RAGE and its emerging role in the pathogenesis of Parkinson's disease

Neuroscience Letters
Xiuli JiangAnmu Xie

Abstract

Receptor for advanced glycation end products (RAGE) is a multiligand receptor belonging to the immunoglobulin superfamily and plays crucial roles in the development of many human diseases such as neurodegenerative diseases, diabetes, cardiovascular diseases, osteoarthritis and cancer. RAGE involves in a number of cell processes such as neuroinflammation, apoptosis, proliferation and autophagy. In CNS, RAGE was primarily expressed in neurons, microglia and vascular endothelial cells. Interacting with ligands, RAGE induces a series of signal transduction cascades and leads to the activation of transcription factor NF-κB as well as increased expression of cytokines like TNF-α, IL-1. Moreover, binding to RAGE can also stimulate the generation of reactive oxygen species (ROS), which is implicated in neuron death. It was reported that RAGE were highly expressed in PD patients when compared to age-matched controls. And RAGE ablation protected nigral dopaminergic neurons against cell death in MPTP treated mice. Here we review this article to elucidate the role of RAGE in PD pathogenesis and highlight the anti-RAGE strategies in the treatment of PD.

Citations

May 5, 2018·Environmental Microbiology·Antoine Danchin
Sep 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Judy PotashkinConnie Marras
May 28, 2020·International Journal of Molecular Sciences·Mark F McCarty, Aaron Lerner
Jan 9, 2021·The Journal of Experimental Medicine·Luigi FontanaLaura Piccio
Oct 15, 2020·Cellular and Molecular Life Sciences : CMLS·Efthalia AngelopoulouChristina Piperi
Feb 8, 2020·Current Neuropharmacology·Shareen Singh, Thakur Gurjeet Singh

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