Raging the War Against Inflammation With Natural Products

Frontiers in Pharmacology
Ali AttiqWaqas Ahmad

Abstract

Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of choice for treating numerous inflammatory diseases including rheumatoid arthritis. The NSAIDs produces anti-inflammatory activity via inhibiting cyclooxygenase enzyme, responsible for the conversation of arachidonic acid to prostaglandins. Likewise, cyclooxegenase-2 inhibitors (COX-2) selectively inhibit the COX-2 enzyme and produces significant anti-inflammatory, analgesic, and anti-pyretic activity without producing COX-1 associated gastrointestinal and renal side effects. In last two decades numerous selective COX-2 inhibitors (COXIBs) have been developed and approved for various inflammatory conditions. However, data from clinical trials have suggested that the prolong use of COX-2 inhibitors are also associated with life threatening cardiovascular side effects including ischemic heart failure and myocardial infection. In these scenario secondary metabolites from natural product offers a great hope for the development of novel anti-inflammatory compounds. Although majority of the natural product based compounds exhibit more selectively toward COX-1. However, the data suggest that slight structural modification can be helpful in developi...Continue Reading

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Citations

May 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dawoon JeongJae-Ha Ryu
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Jul 14, 2020·Drug and Chemical Toxicology·Mohammad MazaniAhmad Salimi
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Apr 30, 2021·Research in Veterinary Science·Mahmoud AlagawanyKuldeep Dhama
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boon-Peng PuahYusof Kamisah
Jun 10, 2020·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Sabrina HadjiraSouad Ameddah
Feb 7, 2020·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Ozkan Karatas, Fikret Gevrek

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Methods Mentioned

BETA
chromosomal aberration
nuclear translocation

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