Ragweed-induced allergic rhinoconjunctivitis: current and emerging treatment options

Journal of Asthma and Allergy
Friedrich Ihler, Martin Canis

Abstract

Ragweed (Ambrosia spp.) is an annually flowering plant whose pollen bears high allergenic potential. Ragweed-induced allergic rhinoconjunctivitis has long been seen as a major immunologic condition in Northern America with high exposure and sensitization rates in the general population. The invasive occurrence of ragweed (A. artemisiifolia) poses an increasing challenge to public health in Europe and Asia as well. Possible explanations for its worldwide spread are climate change and urbanization, as well as pollen transport over long distances by globalized traffic and winds. Due to the increasing disease burden worldwide, and to the lack of a current and comprehensive overview, this study aims to review the current and emerging treatment options for ragweed-induced rhinoconjunctivitis. Sound clinical evidence is present for the symptomatic treatment of ragweed-induced allergic rhinoconjunctivitis with oral third-generation H1-antihistamines and leukotriene antagonists. The topical application of glucocorticoids has also been efficient in randomized controlled clinical trials. Combined approaches employing multiple agents are common. The mainstay of causal treatment to date, especially in Northern America, is subcutaneous immun...Continue Reading

Citations

Sep 19, 2015·Current Allergy and Asthma Reports·Véronique Bordas-Le FlochPhilippe Moingeon
Nov 2, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Agata SchrammTomasz P Mikolajczyk
Apr 27, 2021·Clinical and Translational Allergy·Anne M SalapatekAndreas Bilstein

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