PMID: 6107453Oct 11, 1980Paper

Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients

Lancet
P AlbrechtN Daniel

Abstract

The serum and cerebrospinal fluid (CSF) of 60 schizophrenic patients and 26 controls were analysed for viral antibody against cytomegalovirus (CMV), vaccinia virus, herpes simplex virus type 1 (HSV), and type A influenza virus. A CSF/serum antibody ratio more than 2 standard deviations above the mean of the controls suggested local antibody production in the central nervous system. 68% of the patients had an increased CSF/serum antibody ratio for CMV antibody, 14% for vaccinia antibody, 4% for HSV antibody, and 15% for influenza virus antibody.

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